Evidence map›Paper›PMID 38422874›Full record

ArticleEnvironment international2024

Diesel exhaust and respiratory dust exposure in miners and chronic obstructive pulmonary disease (COPD) mortality in DEMS II.

Andreas M Neophytou, Jacqueline M Ferguson, Sadie Costello, Sally Picciotto, John R Balmes, Stella Koutros, Debra T Silverman, Ellen A Eisen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Andreas M NeophytouDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA. Electronic address: Andreas.Neophytou@colostate.edu.
Jacqueline M FergusonDivision of Primary Care and Population Health, Stanford University School of Medicine, Stanford, CA, USA; Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Sadie CostelloDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Sally PicciottoDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
John R BalmesDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA; Department of Medicine, University of California, San Francisco, CA, USA.
Stella KoutrosOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, MD, USA.
Debra T SilvermanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, MD, USA.
Ellen A EisenDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
University of California, Berkeley · USNational Institutes of Health · USColorado State University · USStanford Health Care · USUniversity of California, San Francisco · US

Funding

Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

backgroundDiesel exhaust and respirable dust exposures in the mining industry have not been studied in depth with respect to non-malignant respiratory disease including chronic obstructive pulmonary disease (COPD), with most available evidence coming from other settings.

objectivesTo assess the relationship between occupational diesel exhaust and respirable dust exposures and COPD mortality, while addressing issues of survivor bias in exposed miners.

methodsThe study population consisted of 11,817 male workers from the Diesel Exhaust in Miners Study II, followed from 1947 to 2015, with 279 observed COPD deaths. We fit Cox proportional hazards models for the relationship between respirable elemental carbon (REC) and respirable dust (RD) exposure and COPD mortality. To address healthy worker survivor bias, we leveraged the parametric g-formula to assess effects of hypothetical interventions on both exposures.

resultsCox models yielded elevated estimates for the associations between average intensity of REC and RD and COPD mortality, with hazard ratios (HR) corresponding to an interquartile range width increase in exposure of 1.46 (95 % confidence interval (CI): 1.12, 1.91) and 1.20 (95 % CI: 0.96, 1.49), respectively for each exposure. HRs for cumulative exposures were negative for both REC and RD. Based on results from the parametric g-formula, the risk ratio (RR) for COPD mortality comparing risk under an intervention eliminating REC to the observed risk was 0.85 (95 % CI: 0.55, 1.06), equivalent to an attributable risk of 15 %. The corresponding RR comparing risk under an intervention eliminating RD to the observed risk was 0.93 (95 % CI: 0.56, 1.31).

conclusionsOur findings, based on data from a cohort of nonmetal miners, are suggestive of an increased risk of COPD mortality associated with REC and RD, as well as evidence of survivor bias in this population leading to negative associations between cumulative exposures and COPD mortality in traditional regression analysis.

Indexed as

Air Pollutants, OccupationalOccupational ExposurePulmonary Disease, Chronic ObstructiveCarbonDustHumansMaleVehicle EmissionsAir Pollutants, OccupationalCarbonDustVehicle EmissionsCOPD mortalityDiesel exhaustRespiratory dustSurvivor bias

Identifiers

PMID38422874
PMCPMC10961191
OpenAlexW4392128336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.