ArticleNeuroImage. Clinical2024
A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry.
Article in NeuroImage. Clinical, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Aberrant cortical-subcortical-cerebellar connectivity in resting-state fMRI as an imaging marker of schizophrenia and psychosis: a systematic review of data-driven whole-brain functional connectivity analyses.Frontiers in neuroimaging · 2025Pooled it
- Transdiagnostic markers across the psychosis continuum: a systematic review and meta-analysis of resting state fMRI studies.Frontiers in psychiatry · 2024Pooled it
- Mapping the psychosis spectrum - imaging neurosubtypes from multiscale functional network connectivity.Molecular psychiatry · 2026Article
- What Static Connectivity Misses: Dynamic Alpha-Band Brain Network States in First-Episode Psychosis.Brain topography · 2026Article
- Classifying schizophrenia patients and healthy individuals: Whole brain SPECT functional connectivity using support vector machine classification.Neuroimage. Reports · 2026Article
- A Replicable NeuroMark Template for Whole-Brain SPECT Reveals Data-Driven Perfusion Networks and Their Alterations in Schizophrenia.Neuroinformatics · 2026Article
- Prefrontal Circuitry Abnormalities and Cognitive Impairment in Adolescents with Early- Onset Psychosis.Research square · 2026Article
- Associations between negative symptoms and resting-state functional connectivity within social brain networks among individuals with early psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Brain functional network connectivity interpolation characterizes the neuropsychiatric continuum and heterogeneity.bioRxiv : the preprint server for biology · 2026Article
- Functional Coupling and Longitudinal Outcome Prediction in First-Episode Psychosis.Biological psychiatry global open science · 2025Article
- Toward Granular Brain Intrinsic Connectivity Networks and Insights into Schizophrenia.bioRxiv : the preprint server for biology · 2025Article
- Identifying neurobiological heterogeneity in clinical high-risk psychosis: a data-driven biotyping approach using resting-state functional connectivity.Schizophrenia (Heidelberg, Germany) · 2025Article
- Causal Central Network Remodeling in Diabetic Neuropathy: An Integrated MR-fMRI Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Ultrafine brain intrinsic connectivity networks template via very-high-order independent component analysis of large-scale resting-state functional magnetic resonance imaging data.Frontiers in neuroscience · 2025Article
- Addressing Inconsistency in Functional Neuroimaging: A Replicable Data-Driven Multi-Scale Functional Atlas for Canonical Brain Networks.bioRxiv : the preprint server for biology · 2024Article
- Brain functional network connectivity interpolation characterizes the neuropsychiatric continuum and heterogeneity.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
Psychosis (including symptoms of delusions, hallucinations, and disorganized conduct/speech) is a main feature of schizophrenia and is frequently present in other major psychiatric illnesses. Studies in individuals with first-episode (FEP) and early psychosis (EP) have the potential to interpret aberrant connectivity associated with psychosis during a period with minimal influence from medication and other confounds. The current study uses a data-driven whole-brain approach to examine patterns of aberrant functional network connectivity (FNC) in a multi-site dataset comprising resting-state functional magnetic resonance images (rs-fMRI) from 117 individuals with FEP or EP and 130 individuals without a psychiatric disorder, as controls. Accounting for age, sex, race, head motion, and multiple imaging sites, differences in FNC were identified between psychosis and control participants in cortical (namely the inferior frontal gyrus, superior medial frontal gyrus, postcentral gyrus, supplementary motor area, posterior cingulate cortex, and superior and middle temporal gyri), subcortical (the caudate, thalamus, subthalamus, and hippocampus), and cerebellar regions. The prominent pattern of reduced cerebellar connectivity in psychosis is especially noteworthy, as most studies focus on cortical and subcortical regions, neglecting the cerebellum. The dysconnectivity reported here may indicate disruptions in cortical-subcortical-cerebellar circuitry involved in rudimentary cognitive functions which may serve as reliable correlates of psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.