ArticleThe Journal of organic chemistry2024
Stereoselective Amine Synthesis Mediated by a Zirconocene Hydride to Accelerate a Drug Discovery Program.
Article in The Journal of organic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Zirconium-Catalyzed Reductive Sulfonamidation of Amides and Its Application to Site-SelectiveACS catalysis · 2025Article
- Deoxygenative photochemical alkylation of secondary amides enables a streamlined synthesis of substituted amines.Nature communications · 2025Article
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Authors and funding
10 authors.
Funding
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Abstract
Chiral amine synthesis remains a significant challenge in accelerating the design cycle of drug discovery programs. A zirconium hydride, due to its high oxophilicity and lower reactivity, gave highly chemo- and stereoselective reductions of sulfinyl ketimines. The development of this zirconocene-mediated reduction helped to accelerate our drug discovery efforts and is applicable to several motifs commonly used in medicinal chemistry. Computational investigation supported a cyclic half-chair transition state to rationalize the high selectivity in benzyl systems.
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Registered trials
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