Evidence map›Paper›PMID 38422393›Full record

ReviewChemical reviews2024

Theranostic Fluorescent Probes.

Amit Sharma, Peter Verwilst, Mingle Li, Dandan Ma, Nem Singh, Jiyoung Yoo, Yujin Kim, Ying Yang, Jing-Hui Zhu, Haiqiao Huang and 7 more

Open access · hybridAbstract readReview
In one paragraph

Review in Chemical reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
68.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 372 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Modern Cyanine Dye-Based Photosensitizers for Medical Applications.Angewandte Chemie (International ed. in English) · 2026
    Review
  7. Review
  8. Mitochondria-Damaging Self-Reporting Probe for Cancer Therapy.Angewandte Chemie (International ed. in English) · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 5 countries.

Amit SharmaAmity School of Chemical Sciences, Amity University Punjab, Sector 82A, Mohali 140 306, India.ORCID 0000-0003-2815-8208
Peter VerwilstRega Institute for Medical Research, Medicinal Chemistry, KU Leuven, Herestraat 49, Box 1041, 3000 Leuven, Belgium.ORCID 0000-0002-4673-2050
Mingle LiCollege of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0002-0384-9128
Dandan MaCollege of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
Nem SinghDepartment of Chemistry, Korea University, Seoul 02841, Korea.ORCID 0000-0003-2952-3385
Jiyoung YooDepartment of Chemistry, Korea University, Seoul 02841, Korea.
Yujin KimDepartment of Chemistry, Korea University, Seoul 02841, Korea.
Ying YangSchool of Light Industry and Food Engineering, Guangxi University, Nanning, Guangxi 530004, China.
Jing-Hui ZhuCollege of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
Haiqiao HuangCollege of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
Xi-Le HuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Xiao-Peng HeKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.ORCID 0000-0002-8736-3511
Lintao ZengSchool of Light Industry and Food Engineering, Guangxi University, Nanning, Guangxi 530004, China.
Tony D JamesDepartment of Chemistry, University of Bath, Bath BA2 7AY, United Kingdom.ORCID 0000-0002-4095-2191
Xiaojun PengCollege of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0002-8806-322X
Jonathan L SesslerDepartment of Chemistry, The University of Texas at Austin, Texas 78712-1224, United States.ORCID 0000-0002-9576-1325
Jong Seung KimDepartment of Chemistry, Korea University, Seoul 02841, Korea.ORCID 0000-0003-3477-1172
Shenzhen University · CNKorea University · KREast China University of Science and Technology · CNGuangxi University · CNRega Institute for Medical Research · BEThe University of Texas at Austin · USUniversity of Bath · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal control, in the context of drug delivery makes theranostic fluorescent probes an attractive and intensely investigated research topic. This interest is reflected in the steep rise in publications on the topic that have appeared over the past decade. Theranostic fluorescent probes, in their various incarnations, generally comprise a fluorophore linked to a masked drug, in which the drug is released as the result of certain stimuli, with both intrinsic and extrinsic stimuli being reported. This release is then signaled by the emergence of a fluorescent signal. Importantly, the use of appropriate fluorophores has enabled not only this emerging fluorescence as a spatiotemporal marker for drug delivery but also has provided modalities useful in photodynamic, photothermal, and sonodynamic therapeutic applications. In this review we highlight recent work on theranostic fluorescent probes with a particular focus on probes that are activated in tumor microenvironments. We also summarize efforts to develop probes for other applications, such as neurodegenerative diseases and antibacterials. This review celebrates the diversity of designs reported to date, from discrete small-molecule systems to nanomaterials. Our aim is to provide insights into the potential clinical impact of this still-emerging research direction.

Indexed as

Fluorescent DyesPrecision MedicineCell Line, TumorDrug Delivery SystemsFluorescenceTheranostic NanomedicineFluorescent Dyes

Identifiers

PMID38422393
PMCPMC11132561
OpenAlexW4392282159

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.