SynthesisActa cirurgica brasileira2024
Clinical behavior of recurrent pleomorphic adenoma in the palate: a systematic review.
Synthesis in Acta cirurgica brasileira, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 2 citations in OpenAlex.
- Recurrent Pleomorphic Adenoma of the Palate: A Case Report.Clinics and practice · 2026Article
- Pleomorphic Adenoma of a Minor Salivary Gland of the Hard Palate Complicated by Surgical Site Infection: A Case Report.International medical case reports journal · 2026Article
- Pleomorphic Adenoma of the Soft Palate: Case Report.Case reports in medicine · 2025Article
- Decoding a Rare Case of Pleomorphic Adenoma: A Case Report and Review of the Literature.Cureus · 2024Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis systematic review analyzed the clinical behavior and odds of malignancy of the palatal recurrent pleomorphic adenomas.
methodsSystematic review of patients with recurrent pleomorphic adenoma arising in the palate. Database search: MEDLINE, Scopus, Web of Science, Cochrane, EMBASE, Virtual Health Library, Google Scholar, and OpenGrey. A binomial logistic regression was performed to assess the odds of detecting recurrence five, 10 and 20 years after the treatment of primary tumor.
resultsThirteen studies (n = 18 patients) out of 336 were included. The recurrent pleomorphic adenoma in palate was more common in females (61.6%), average age was 49 years old (range 9-73 years old). Four patients progressed to malignant transformation. The odds ratio (OR) of detecting a recurrence at 10 (OR = 5.57; 95% confidence interval - 95%CI 1.13-27.52), and 20 years (OR = 18.78; 95%CI 3.18-110.84) after treatment of primary pleomorphic adenoma was significantly higher than at one-year follow-up.
conclusionsThe recurrence of pleomorphic adenoma in palate remains a rare event of late occurrence. It mainly affects middle-aged female and carries a risk of malignant transformation. Although uncommon, patients with palatal pleomorphic adenoma should be warned about the possibility of recurrence or malignant transformation of tumor at advanced ages.
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