Evidence map›Paper›PMID 38422030›Full record

ArticleThe Journal of international medical research2024

Philadelphia chromosome-positive T-cell acute lymphoblastic leukemia: a case report.

Qianze Dong, Tarneem Darwish, Meyerson Howard, Shashirekha Shetty, Yang Wang, Yan Xiu, Molly Gallogly, Chen Zhao

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qianze DongDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Tarneem DarwishDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Meyerson HowardDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Shashirekha ShettyDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Yang WangDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Yan XiuDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Molly GalloglyDepartment of Hematology and Oncology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Chen ZhaoDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0003-3217-0269

Funding

Heat Shock Transcription Factor 1 Specifically Regulates AML Stem Cell Self-RenewalR01CA237006 · NCI · UNIVERSITY OF IOWA · PI ZHAO, CHEN · 2020 to 2024
$1.9M
Synergy of NF-kB and Notch signaling in B cell lymphomatous transformation and B cell plasticityI01BX004255 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI ZHAO, CHEN · 2019 to 2022
–
BLRD VA I01 BX004255NCI NIH HHS R01 CA237006
6 · The paper itself

Abstract

Philadelphia chromosome-positive (Ph+) T-cell acute lymphoblastic leukemia (T-ALL) is a rare and aggressive type of acute leukemia. The Philadelphia chromosome is the hallmark of chronic myeloid leukemia (CML). The differentiation between Ph+ T-ALL and T-cell lymphoblastic crisis of CML may be problematic in some cases. Here, we report a rare case of de novo Ph+ T-ALL that presented a diagnostic challenge. The overall clinical, immunophenotypic, cytogenetic, and xenotransplantation results suggest a diagnosis of Ph+ T-ALL. The patient was treated with induction chemotherapy including imatinib followed by haploidentical stem cell transplantation and achieved complete remission.

Indexed as

Leukemia, Myelogenous, Chronic, BCR-ABL PositivePrecursor Cell Lymphoblastic Leukemia-LymphomaPrecursor T-Cell Lymphoblastic Leukemia-LymphomaHumansPhiladelphia ChromosomeT-LymphocytesBCR-ABL1case reportchronic myeloid leukemiadiagnosisPhiladelphia chromosomeT-cell acute lymphoblastic leukemia

Identifiers

PMID38422030
PMCPMC10906060

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.