Mitigating bisphenol A-induced apoptosis in KGN cells: the therapeutic role of 1,25-dihydroxyvitamin D

Liting Tang, Ke Du, Kaiming Luo, Long Wang, Fei Hua

Abstract read

In one paragraph

Article in Hormones (Athens, Greece), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Lycopene attenuates DEHP-induced oxidative stress, mitochondrial dysfunction, and apoptosis in human granulosa cells via SIRT1-dependent mechanisms.BMC pharmacology & toxicology · 2026
Article
Integrative bioinformatics, single-cell and experimental evidence for a BPA-m6A-apoptosis axis in granulosa cell dysfunction in polycystic ovary syndrome.Journal of ovarian research · 2026
Article
Network toxicology and single-cell analysis reveal key gene-mediated bisphenol a interference with granulosa cell function in polycystic ovary syndrome.Frontiers in pharmacology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liting TangDepartment of Endocrinology and Metabolism, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.

Ke DuDepartment of Endocrinology and Metabolism, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.

Kaiming LuoDepartment of Endocrinology and Metabolism, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.

Long WangDepartment of Endocrinology and Metabolism, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.

Fei HuaDepartment of Endocrinology and Metabolism, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China. huafei1970@suda.edu.cn.ORCID http://orcid.org/0009-0005-8066-2921

Funding

Changzhou Key Medical Discipline CZXK202201Changzhou Sci&Tech Program CJ20220063

6 · The paper itself

Abstract

purposeThis study investigated the potential of 1,25-dihydroxyvitamin D

methodsThe impact of varying concentrations of BPA and 1,25(OH)

resultsBPA induced a notable increase in apoptosis (P < 0.001) and oxidative stress (P < 0.001) in KGN cells, accompanied by a significant reduction in mitochondrial membrane potential (P < 0.001) and severe impairment of mitochondrial function. Following pretreatment of KGN cells with 1,25(OH)

conclusions1,25(OH)

Indexed as

ApoptosisBenzhydryl CompoundsCytochromes cMitochondriaPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhenolsUp-RegulationBisphenol A CompoundsCalcitriolCell LineFemaleGranulosa CellsHumansOxidative StressReactive Oxygen SpeciesVitamin DBenzhydryl Compoundsbisphenol ABisphenol A CompoundsCalcitriolCytochromes cPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhenolsPPARGC1A protein, humanReactive Oxygen SpeciesVitamin D1,25-dihydroxyvitamin D3ApoptosisBisphenol AKGN cellsPolycystic ovary syndrome

Identifiers

PMID38421590

DOI10.1007/s42000-024-00539-w

PMCPMC11436470

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.