ArticleThe international journal of cardiovascular imaging2024
Spectral computed tomography angiography using a gadolinium-based contrast agent for imaging of pathologies of the aorta.
Article in The international journal of cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 3 citations in OpenAlex.
- Lumen imaging in calcified coronary arteries using high-resolution Gd-enhanced color K-edge imaging with spectral photon-counting CT: a phantom study.European radiology experimental · 2026Article
- Reevaluating aortic imaging: gadolinium-based spectral CT angiography.The international journal of cardiovascular imaging · 2024Article
- Gadolinium-based coronary CT angiography on a clinical photon-counting-detector system: a dynamic circulating phantom study.European radiology experimental · 2024Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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Abstract
objectivesEspecially patients with aortic aneurysms and multiple computed tomography angiographies (CTA) might show medical conditions which oppose the use of iodine-based contrast agents. CTA using monoenergetic reconstructions from dual layer CT and gadolinium (Gd-)based contrast agents might be a feasible alternative in these patients. Therefore, the purpose of this study was to evaluate the feasibility of clinical spectral CTA with a Gd-based contrast agent in patients with aortic aneurysms.
methodsTwenty-one consecutive scans in 15 patients with and without endovascular aneurysm repair showing contraindications for iodine-based contrast agents were examined using clinical routine doses (0.2 mmol/kg) of Gd-based contrast agent with spectral CT. Monoenergetic reconstructions of the spectral data set were computed.
resultsThere was a significant increase in the intravascular attenuation of the aorta between pre- and post-contrast images for the MonoE40 images in the thoracic and the abdominal aorta (p < 0.001 for both). Additionally, the ratio between pre- and post-contrast images was significantly higher in the MonoE40 images as compared to the conventional images with a factor of 6.5 ± 4.5 vs. 2.4 ± 0.5 in the thoracic aorta (p = 0.003) and 4.1 ± 1.8 vs. 1.9 ± 0.5 in the abdominal aorta (p < 0.001).
conclusionsTo conclude, our study showed that Gd-CTA is a valid and reliable alternative for diagnostic imaging of the aorta for clinical applications. Monoenergetic reconstructions of computed tomography angiographies using gadolinium based contrast agents may be a useful alternative in patients with aortic aneurysms and contraindications for iodine based contrast agents.
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