Application of near infra-red laser light increases current threshold in optic nerve consistent with increased Na

Hin Heng Lo, Tawan Munkongcharoen, Rosa M Muijen, Ritika Gurung, Anjali G Umredkar, Mark D Baker

Abstract read

In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hin Heng LoNeuroscience, Surgery and Trauma, Blizard Institute, QMUL, Whitechapel, London, E1 2AT, UK.

Tawan MunkongcharoenNeuroscience, Surgery and Trauma, Blizard Institute, QMUL, Whitechapel, London, E1 2AT, UK.

Rosa M MuijenNeuroscience, Surgery and Trauma, Blizard Institute, QMUL, Whitechapel, London, E1 2AT, UK.

Ritika GurungNeuroscience, Surgery and Trauma, Blizard Institute, QMUL, Whitechapel, London, E1 2AT, UK.

Anjali G UmredkarNeuroscience, Surgery and Trauma, Blizard Institute, QMUL, Whitechapel, London, E1 2AT, UK.

Mark D BakerNeuroscience, Surgery and Trauma, Blizard Institute, QMUL, Whitechapel, London, E1 2AT, UK. mark.5.baker@kcl.ac.uk.ORCID 0000-0003-1926-8763

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increases in the current threshold occur in optic nerve axons with the application of infra-red laser light, whose mechanism is only partly understood. In isolated rat optic nerve, laser light was applied near the site of electrical stimulation, via a flexible fibre optic. Paired applications of light produced increases in threshold that were reduced on the second application, the response recovering with increasing delays, with a time constant of 24 s. 3-min duration single applications of laser light gave rise to a rapid increase in threshold followed by a fade, whose time-constant was between 40 and 50 s. After-effects were sometimes apparent following the light application, where the resting threshold was reduced. The increase in threshold was partially blocked by 38.6 mM Li

Indexed as

AxonsLasersOptic NerveSodiumAnimalsBumetanideMaleMembrane PotentialsRatsRats, Sprague-DawleyBumetanideSodiumCurrent thresholdInfra-red laserMembrane excitabilityOptic nerve

Identifiers

PMID38421407

DOI10.1007/s00424-024-02932-1

PMCPMC11033230

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.