Evidence map›Paper›PMID 38421322›Full record

ArticleGlobal spine journal2024

AO Spine Guideline for the Use of Osteobiologics (AOGO) in Anterior Cervical Discectomy and Fusion for Spinal Degenerative Cases.

Hans Jörg Meisel, Amit Jain, Yabin Wu, Christopher T Martin, Juan Pablo Cabrera, Sathish Muthu, Waeel O Hamouda, Ricardo Rodrigues-Pinto, Jacobus J Arts, Arun-Kumar Viswanadha and 21 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Global spine journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Synthetic osteobiologics in spine surgery: a review.Turkish journal of medical sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 20 institutions in 17 countries.

Hans Jörg MeiselDepartment of Neurosurgery, BG Klinikum Bergmannstrost Halle, Halle, Germany.ORCID 0000-0003-3838-1489
Amit JainDepartment of Orthopaedic Surgery, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-9983-3365
Yabin WuResearch Department, AO Spine, AO Foundation, Davos, Switzerland.ORCID 0000-0002-1836-7674
Christopher T MartinDepartment of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN, USA.
Juan Pablo CabreraDepartment of Neurosurgery, Hospital Clínico Regional de Concepción, Concepción, Chile; Faculty of Medicine, University of Concepción, Concepción, Chile.ORCID 0000-0003-4685-6106
Sathish MuthuDepartment of Orthopaedics, Government Medical College, Dindigul, India; Orthopaedic Research Group, Coimbatore, TN, India.ORCID 0000-0002-7143-4354
Waeel O HamoudaDepartment of Neurosurgery, Kasr Alainy Faculty of Medicine, Research, and Teaching Hospitals, Cairo University, Cairo, Egypt; Neurological & Spinal Surgery Service, Security Forces Hospital, Dammam, Saudi Arabia.ORCID 0000-0002-4627-0992
Ricardo Rodrigues-PintoSpinal Unit (UVM), Department of Orthopaedics, Centro Hospitalar Universitário do Porto, Porto, Portugal; Hospital CUF Trindade, Porto, Portugal; Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.ORCID 0000-0002-6903-348X
Jacobus J ArtsLaboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, CAPHRI, Maastricht University Medical Center, Maastricht, The Netherlands; Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Arun-Kumar ViswanadhaDepartment of Spine Surgery, Reva Spine Centre, Visakhapatnam, India.
Gianluca VadalàOperative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
Pieter-Paul A VergroesenDepartment of Orthopedic Surgery, Noordwest Hospitals, Alkmaar, The Netherlands.
Stipe ĆorlukaSpinal Surgery Division, Department of Traumatology, University Hospital Centre Sestre Milosrdnice, Zagreb, Croatia; Department of Anatomy and Physiology, University of Applied Health Sciences, Zagreb, Croatia.ORCID 0000-0002-5732-1150
Patrick C HsiehDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-7206-4842
Andreas K DemetriadesDepartment of Neurosurgery, Royal Infirmary of Edinburgh, Scotland, UK.ORCID 0000-0002-2004-9448
Kota WatanabeDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
John H ShinDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
K Daniel RiewDepartment of Neurological Surgery, Weill Cornell Medical College, Cornell University, New York, NY, USA; Department of Orthopedic Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0002-0718-3423
Luca PapaveroClinic for Spine Surgery, Schoen Clinic Hamburg Eilbek, Hamburg, Germany.ORCID 0000-0002-3664-8736
Gabriel LiuDepartment of Orthopedic Surgery, National University Hospital, Singapore, Singapore.
Zhuojing LuoDepartment of Orthopaedic Surgery, Xijing Hospital, Xi'an, China.
Sashin AhujaWelsh Centre for Spinal Surgery & Trauma, Department of Spine Surgery, University Hospital of Wales, Cardiff, UK.
Tamás FeketeSpine Center Division, Schulthess Klinik, Zurich, Switzerland.
Atiq Uz ZamanOrthopaedic and Spine Surgery Department, Lahore Medical and Dental College, Ghurki Trust Teaching Hospital, Lahore, Pakistan.
Mohammad El-SharkawiDepartment of Orthopaedic and Trauma Surgery, Faculty of Medicine, Assiut University, Assiut, Egypt.ORCID 0000-0001-6177-7145
Daisuke SakaiDepartment of Orthopaedic Surgery, Tokai University School of Medicine, Isehara, Japan.
Samuel K ChoDepartment of Orthopedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jeffrey C WangDepartment of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Tim YoonDepartment of Orthopaedics, Emory University, Atlanta, GA, USA.ORCID 0000-0003-1010-6952
Nancy SantessoDepartment of Health Research Methods Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Zorica BuserGerling Institute, Brooklyn, NY, USA; Department of Orthopedic Surgery, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-5680-0643
University of Southern California · USAO Foundation · CHAssiut University · EGBG Klinikum Bergmannstrost Halle · DECairo University · EGCMH Lahore Medical College and Institute of Dentistry · PKCornell University · USEdinburgh Royal Infirmary · GBEmory University · USIcahn School of Medicine at Mount Sinai · USImpact · CAJohns Hopkins University · USKeio University · JPMaastricht University · NLMassachusetts General Hospital · USNational University Hospital · SGNoordwest Ziekenhuisgroep · NLOrthopaedic Research Group · INSchön Klinik Hamburg Eilbek · DESchulthess-Klinik · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designGuideline.

objectivesTo develop an international guideline (AOGO) about the use of osteobiologics in anterior cervical discectomy and fusion (ACDF) for treating degenerative spine conditions.

methodsThe guideline development process was guided by AO Spine Knowledge Forum Degenerative (KF Degen) and followed the Guideline International Network McMaster Guideline Development Checklist. The process involved 73 participants with expertise in degenerative spine diseases and surgery from 22 countries. Fifteen systematic reviews were conducted addressing respective key topics and evidence was collected. The methodologist compiled the evidence into GRADE Evidence-to-Decision frameworks. Guideline panel members judged the outcomes and other criteria and made the final recommendations through consensus.

resultsFive conditional recommendations were created. A conditional recommendation is about the use of allograft, autograft or a cage with an osteobiologic in primary ACDF surgery. Other conditional recommendations are about the use of osteobiologic for single- or multi-level ACDF, and for hybrid construct surgery. It is suggested that surgeons use other osteobiologics rather than human bone morphogenetic protein-2 (BMP-2) in common clinical situations. Surgeons are recommended to choose 1 graft over another or 1 osteobiologic over another primarily based on clinical situation, and the costs and availability of the materials.

conclusionThis AOGO guideline is the first to provide recommendations for the use of osteobiologics in ACDF. Despite the comprehensive searches for evidence, there were few studies completed with small sample sizes and primarily as case series with inherent risks of bias. Therefore, high-quality clinical evidence is demanded to improve the guideline.

Indexed as

anterior cervical discectomy and fusionAOGOautograftguidelineosteobiologicssystematic review

Identifiers

PMID38421322
PMCPMC10913909
OpenAlexW4392302308

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.