Evidence map›Paper›PMID 38421191›Full record

ArticleMicrobiology spectrum2024

Identification of fungal natural products with potent inhibition in

Tiantian Jiang, Karla P Godinez-Macias, Jennifer E Collins, Jin Woo Lee, Karen L Wendt, Krypton Carolino, Debopam Chakrabarti, Robert H Cichewicz, Elizabeth A Winzeler

Abstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Discovery of novel anti-RSC advances · 2026
    Article
  2. Antimalarial cytoskeletal targeting with broad apicomplexan activity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Draft genome sequence of the peptaibol producerMicrobiology resource announcements · 2026
    Article
  4. Marine natural products.Natural product reports · 2026
    Review
  5. Article
  6. Tartrolon E rapidly blocks Toxoplasma gondii capacity to invade host cells.International journal for parasitology. Drugs and drug resistance · 2025
    Article
  7. Review
  8. Fungal-derived methyldeoxaphomins targetProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Novel Drug Targets for the Bradyzoite Form ofResearch and reports in tropical medicine · 2025
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tiantian JiangDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0002-4875-3613
Karla P Godinez-MaciasDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Jennifer E CollinsDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.
Jin Woo LeeCollege of Pharmacy, Duksung Women's University, Seoul, Republic of Korea.
Karen L WendtNatural Products Discovery Group, Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Krypton CarolinoDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Debopam ChakrabartiDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.
Robert H CichewiczNatural Products Discovery Group, Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Elizabeth A WinzelerDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0002-4049-2113

Funding

Novel Antimalarials from FungiR01AI154777 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI CHAKRABARTI, DEBOPAM, CICHEWICZ, ROBERT HENRY · 2020 to 2024
$3.8M
Cocaine Vaccine for Methadone Maintained PatientsR01DA015477 · NIDA · YALE UNIVERSITY · PI ROUNSAVILLE, BRUCE · 2002 to 2006
$1.7M
NIAID NIH HHS R01 AI154777NIDA NIH HHS R01 DA015477
6 · The paper itself

Abstract

In an effort to identify novel compounds with potent inhibition against IMPORTANCE: Current therapeutics for treating toxoplasmosis remain insufficient, demonstrating high cytotoxicity, poor bioavailability, limited efficacy, and drug resistance. Additional research is needed to develop novel compounds with high efficacy and low cytotoxicity. The success of artemisinin and other natural products in treating malaria highlights the potential of natural products as anti-protozoan therapeutics. However, the exploration of natural products in

Indexed as

Antiprotozoal AgentsArtemisininsBiological ProductsMalariaToxoplasmaToxoplasmosisHumansAntiprotozoal AgentsArtemisininsBiological Productsfumagillinfungal natural productsheptelidic acidpeptaibolscaffold discoveryToxoplasma gondiixanthoquinodin

Identifiers

PMID38421191
PMCPMC10986609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.