Evidence map›Paper›PMID 38421166›Full record

ArticleJournal of virology2024

PB2 residue 473 contributes to the mammalian virulence of H7N9 avian influenza virus by modulating viral polymerase activity via ANP32A.

Miaomiao Zhang, Mingbin Liu, Hongjun Chen, Tianyi Qiu, Xuanxuan Jin, Weihui Fu, Qiaoyang Teng, Chen Zhao, Jianqing Xu, Zejun Li and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Miaomiao Zhang *Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID 0000-0003-4657-5320
Mingbin Liu *Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Hongjun ChenShanghai Veterinary Research Institute, Shanghai, China.
Tianyi QiuZhongshan Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Xuanxuan JinAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Weihui FuShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Qiaoyang TengShanghai Veterinary Research Institute, Shanghai, China.
Chen ZhaoShanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID 0000-0002-0718-7707
Jianqing XuShanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID 0000-0003-0896-9273
Zejun LiShanghai Veterinary Research Institute, Shanghai, China.ORCID 0000-0003-4368-1988
Xiaoyan ZhangShanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID 0000-0002-3193-1401
Shanghai Veterinary Research Institute · CNFudan University · CNShanghai Public Health Clinical Center · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the first human infection reported in 2013, H7N9 avian influenza virus (AIV) has been regarded as a serious threat to human health. In this study, we sought to identify the virulence determinant of the H7N9 virus in mammalian hosts. By comparing the virulence of the SH/4664 H7N9 virus, a non-virulent H9N2 virus, and various H7N9-H9N2 hybrid viruses in infected mice, we first pinpointed PB2 as the primary viral factor accounting for the difference between H7N9 and H9N2 in mammalian virulence. We further analyzed the

Indexed as

Influenza A Virus, H7N9 SubtypeInfluenza, HumanNuclear ProteinsRNA-Binding ProteinsAnimalsHumansInfluenza A Virus, H9N2 SubtypeMammalsMiceNucleotidyltransferasesRNA-Dependent RNA PolymeraseVirulenceVirus ReplicationANP32A protein, humanAnp32a protein, mouseNuclear ProteinsNucleotidyltransferasesRNA-Binding ProteinsRNA-Dependent RNA PolymeraseANP32AH7N9host specificityPB2viral polymerase activityvirulence

Identifiers

PMID38421166
PMCPMC10949425
OpenAlexW4392285083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.