Evidence map›Paper›PMID 38421139›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

CD38-Specific Gallium-68 Labeled Peptide Radiotracer Enables Pharmacodynamic Monitoring in Multiple Myeloma with PET.

Ajay Kumar Sharma, Kuldeep Gupta, Akhilesh Mishra, Gabriela Lofland, Ian Marsh, Dhiraj Kumar, Gabriel Ghiaur, Philip Imus, Steven P Rowe, Robert F Hobbs and 2 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. AI-guided design of plectin-1-targetedJournal of nanobiotechnology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ajay Kumar SharmaThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Kuldeep GuptaThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Akhilesh MishraThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Gabriela LoflandThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Ian MarshDepartment of Radiation Oncology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Dhiraj KumarThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Gabriel GhiaurThe Sidney Kimmel Comprehensive Cancer Center and the Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Philip ImusThe Sidney Kimmel Comprehensive Cancer Center and the Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Steven P RoweThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Robert F HobbsDepartment of Radiation Oncology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Christian B GockeThe Sidney Kimmel Comprehensive Cancer Center and the Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Sridhar NimmagaddaThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.ORCID 0000-0002-6413-7191
Johns Hopkins University · USBloomberg (United States) · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6M
Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
Clinical translation of a PD-L1 PET tracer to optimize immune checkpoint therapy in patients with non-small cell lung cancersR01CA269235 · NCI · JOHNS HOPKINS UNIVERSITY · PI Sridhar Nimmagadda, STEVEN P ROWE · 2022 to 2026
$3.2M
Non-invasive Quantification of Dose-Exposure-Response of PD-L1 Therapeutics at the TumorR01CA236616 · NCI · JOHNS HOPKINS UNIVERSITY · PI NIMMAGADDA, SRIDHAR · 2018 to 2022
$2.3M
Role of Oncogenic RAS in Multiple Myeloma Disease ProgressionK08CA218893 · NCI · JOHNS HOPKINS UNIVERSITY · PI GOCKE, CHRISTIAN B · 2018 to 2022
$1.1M
NCI NIH HHS K08 CA218893NCI NIH HHS P30 CA006973NCI NIH HHS R01 CA236616NCI NIH HHS R01 CA269235NIBIB NIH HHS P41 EB024495NIH HHS P30CA006973NIH HHS P41EB024495NIH HHS R01CA236616NIH HHS R01CA269235
6 · The paper itself

Abstract

The limited availability of molecularly targeted low-molecular-weight imaging agents for monitoring multiple myeloma (MM)-targeted therapies has been a significant challenge in the field. In response, a first-in-class peptide-based radiotracer, [

Indexed as

ADP-ribosyl Cyclase 1Gallium RadioisotopesMultiple MyelomaPositron-Emission TomographyAnimalsCell Line, TumorDisease Models, AnimalHumansMembrane GlycoproteinsMicePeptidesRadiopharmaceuticalsADP-ribosyl Cyclase 1CD38 protein, humanGallium-68Gallium RadioisotopesMembrane GlycoproteinsPeptidesRadiopharmaceuticalsATRACD38daratumumabisatuximabPETpharmacodynamics

Identifiers

PMID38421139
PMCPMC11040352
OpenAlexW4392285750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.