ArticleCNS neuroscience & therapeutics2024
Stride length and cerebellar regulation: Key features of early gait disorder in cerebral small vessel disease.
Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Transcranial stimulation combined with four rehabilitation therapies for gait and motor function in Parkinson's disease: a network meta-analysis of 23 RCTs.Frontiers in aging neuroscience · 2025Pooled it
- Development and internal validation of a spatiotemporal gait parameter-based diagnostic model for cerebral small vessel disease.Frontiers in aging neuroscience · 2026Article
- Discrepant Spatiotemporal Characteristics of Gait Impairments in Thalamic Infarction Patients.Brain and behavior · 2025Article
- Impact of enlarged perivascular spaces in the basal ganglia on gait in cerebral small vessel disease.Aging clinical and experimental research · 2025Article
- Gait analysis in older adults with mild cognitive impairment: a bibliometric analysis of global trends, hotspots, and emerging frontiers.Frontiers in aging · 2025Article
- Wearable sensors and machine learning fusion-based fall risk prediction in covert cerebral small vessel disease.Frontiers in neuroscience · 2025Article
- Gait Characteristics and Neuroanatomical Alterations in Obstructive Sleep Apnea-Hypopnea Syndrome.Nature and science of sleep · 2025Article
- Stride length and cerebellar regulation: Key features of early gait disorder in cerebral small vessel disease.CNS neuroscience & therapeutics · 2024Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesGait disorder (GD) is a common problem in cerebral small vessel disease (CSVD). This study aimed to determine (1) the early characteristics of GD in CSVD, (2) cerebellar neuroimaging features related to GD in CSVD, and (3) the association of cognitive impairment with GD.
methodsIn total, 183 subjects were enrolled in this study: patients with CSVD with normal cognitive function (CSVD-NC) group (64 subjects), patients with CSVD with mild cognitive impairment (CSVD-MCI) group (66 subjects), and a healthy control (HC) group (53 subjects). The GD patterns were evaluated using the ReadyGo three-dimensional motion balance testing system. Meanwhile, we analyzed the cerebrum and cerebellum structurally and functionally. Correlation analyses were conducted among gait indicators, neuroimaging features, and neuropsychological tests.
resultsBoth the CSVD-NC and CSVD-MCI groups had a reduced stride length, cortical atrophy in the left cerebellum VIIIb, and decreased functional connectivity between the left cerebellum VIIIb and left SFGmed compared with the HC group. In the correlation analysis, the gray matter probability of the left cerebellum VIIIb was closely related to stride length in the HC group. In the CSVD-MCI group, linguistic function, memory, and attention were significantly correlated with gait performance.
conclusionDecreased stride length was the earliest characteristic of GD in CSVD. Structural and functional regulation of the left cerebellum VIIIb could play a particularly important role in early GD in CSVD.
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