Evidence map›Paper›PMID 38420937›Full record

ArticleNanotoxicology2024

Potent lung tumor promotion by inhaled MWCNT.

Dale W Porter, Marlene S Orandle, Ann Hubbs, Lauren M Staska, David Lowry, Michael Kashon, Michael G Wolfarth, Walter McKinney, Linda M Sargent

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanotoxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dale W PorterPathology and Physiology Research Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA.ORCID 0000-0002-8358-6793
Marlene S OrandlePathology and Physiology Research Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
Ann HubbsPathology and Physiology Research Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA.ORCID 0000-0001-8631-5123
Lauren M StaskaCharles River Laboratories, Inc, Durham, NC, USA.
David LowryToxicology and Molecular Biology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA.ORCID 0000-0002-0235-3438
Michael KashonBioanalytics Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA.ORCID 0000-0003-1581-4077
Michael G WolfarthPathology and Physiology Research Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA.ORCID 0000-0002-6273-6019
Walter McKinneyPhysical Effects Research Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA.ORCID 0000-0002-5180-8451
Linda M SargentToxicology and Molecular Biology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
Centers for Disease Control and Prevention · USCharles River Laboratories (United States) · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

In the lung, carcinogenesis is a multi-stage process that includes initiation by a genotoxic agent, promotion that expands the population of cells with damaged DNA to form a tumor, and progression from benign to malignant neoplasms. We have previously shown that Mitsui-7, a long and rigid multi-walled carbon nanotube (MWCNT), promotes pulmonary carcinogenesis in a mouse model. To investigate the potential exposure threshold and dose-response for tumor promotion by this MWCNT, 3-methylcholanthrene (MC) initiated (10 μg/g, i.p., once) or vehicle (corn oil) treated B6C3F1 mice were exposed by inhalation to filtered air or MWCNT (5 mg/m

Indexed as

LungLung NeoplasmsAnimalsCarcinogenesisCell Transformation, NeoplasticInhalation ExposureMiceMice, Inbred C57BLMice, Inbred Strainsinhalation exposurelung cancermiceMulti-walled carbon nanotubestumor promoter

Identifiers

PMID38420937
PMCPMC11057902
OpenAlexW4392294626

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.