Evidence map›Paper›PMID 38420676›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024

Airway tree caliber heterogeneity and airflow obstruction among older adults.

Motahareh Vameghestahbanati, Leina Kingdom, Eric A Hoffman, Miranda Kirby, Norrina B Allen, Elsa Angelini, Alain Bertoni, Qutayba Hamid, James C Hogg, David R Jacobs and 16 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 17 institutions in 4 countries.

Motahareh VameghestahbanatiDepartment of Medicine, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-0651-6537
Leina KingdomDepartment of Medicine, McGill University, Montreal, Quebec, Canada.
Eric A HoffmanDepartment of Radiology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0001-8456-9437
Miranda KirbyDepartment of Physics, Ryerson University, Toronto, Ontario, Canada.
Norrina B AllenCenter for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University, Chicago, Illinois, United States.
Elsa AngeliniFaculty of Medicine, Imperial College London, London, United Kingdom.
Alain BertoniDepartment of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, United States.
Qutayba HamidDepartment of Medicine, McGill University, Montreal, Quebec, Canada.
James C HoggCentre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.
David R JacobsSchool of Public Health, University of Minnesota, Minneapolis, Minnesota, United States.
Andrew LaineDepartment of Medicine, Columbia University, New York, New York, United States.ORCID 0000-0003-3797-0628
Francois MaltaisFaculty of Medicine , University of Laval, Laval, Quebec, Canada.
Erin D MichosFaculty of Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Coralynn SackDepartment of Medicine, University of Washington, Seattle, Washington, United States.
Don SinCentre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-0756-6643
Karol E WatsonDepartment of Medicine, University of California, Los Angeles, California, United States.
Artur WysoczanksiDepartment of Medicine, Columbia University, New York, New York, United States.
David CouperDepartment of Biostatistics, University of North Carolina, North Carolina, United States.
Christopher CooperDepartment of Medicine, University of California, Los Angeles, California, United States.ORCID 0000-0002-6314-0903
Meilan HanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, United States.
Prescott WoodruffDivision of Pulmonary and Critical Care Medicine, University of California, San Francisco, California, United States.
Wan C TanCentre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.
Jean BourbeauDepartment of Medicine, McGill University, Montreal, Quebec, Canada.
R Graham BarrDepartment of Medicine, Columbia University, New York, New York, United States.
Benjamin M SmithDepartment of Medicine, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-0619-5799
investigators from the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study; the Canadian Cohort of Obstructive Lung Disease (CanCOLD); and the Subpopulations and Intermediate Outcome Measures in Chronic Obstructive Pulmonary Disease Study (SPIROMICS)
McGill University · CAColumbia University · USUniversity of British Columbia · CAUniversity of California, Los Angeles · USImperial College Healthcare NHS Trust · GBJohns Hopkins University · USNorthwestern University · USToronto Metropolitan University · CAUniversité Laval · CAUniversity of California, San Francisco · USUniversity of Iowa · USUniversity of Michigan · USUniversity of Minnesota · USUniversity of North Carolina Health Care · USUniversity of Sharjah · AEUniversity of Washington · USWake Forest University · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
Chronic obstructive pulmonary disease in non-smokersR01HL130506 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HERBSTMAN, JULIE BETH, SMITH, BENJAMIN M. · 2016 to 2025
$6.3M
Airway Tree Subtyping on Large Cohorts of CT Images for COPD RiskR01HL155816 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAINE, ANDREW FRANCIS, SMITH, BENJAMIN M. · 2021 to 2024
$2.4M
The Role of Airway Morphology in Environmental LungDiseasesK23ES030725 · NIEHS · UNIVERSITY OF WASHINGTON · PI SACK, CORALYNN SHAYNA · 2019 to 2023
$835k
American Lung Association (ALA)COPD Foundation (Chronic Obstructive Pulmonary Disease Foundation)HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL130506NHLBI NIH HHS R01 HL155816NIDDK NIH HHS P30 DK054759NIEHS NIH HHS K23 ES030725NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Smaller mean airway tree caliber is associated with airflow obstruction and chronic obstructive pulmonary disease (COPD). We investigated whether airway tree caliber heterogeneity was associated with airflow obstruction and COPD. Two community-based cohorts (MESA Lung, CanCOLD) and a longitudinal case-control study of COPD (SPIROMICS) performed spirometry and computed tomography measurements of airway lumen diameters at standard anatomical locations (trachea-to-subsegments) and total lung volume. Percent-predicted airway lumen diameters were calculated using sex-specific reference equations accounting for age, height, and lung volume. The association of airway tree caliber heterogeneity, quantified as the standard deviation (SD) of percent-predicted airway lumen diameters, with baseline forced expired volume in 1-second (FEV

Indexed as

LungPulmonary Disease, Chronic ObstructiveSpirometryAgedAged, 80 and overAirway ObstructionCase-Control StudiesFemaleForced Expiratory VolumeHumansLongitudinal StudiesMaleMiddle AgedTomography, X-Ray ComputedVital Capacityairflow obstructionairway tree caliber heterogeneitychronic obstructive pulmonary diseasecomputed tomography

Identifiers

PMID38420676
PMCPMC11368514
OpenAlexW4392286449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.