Evidence map›Paper›PMID 38420559›Full record

ArticleJTCVS open2024

Type III aortic arch angulation increases aortic stiffness: Analysis from an ex vivo porcine model.

Tim J Mandigers, Ariel F Pascaner, Michele Conti, Martina Schembri, Sonja Jelic, Alessandra Favilli, Daniele Bissacco, Maurizio Domanin, Joost A van Herwaarden, Ferdinando Auricchio and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Tim J MandigersSection of Vascular Surgery, Cardio Thoracic Vascular Department, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Ariel F PascanerCivil Engineering and Architecture Department, Università degli Studi di Pavia, Pavia, Italy.
Michele ContiCivil Engineering and Architecture Department, Università degli Studi di Pavia, Pavia, Italy.
Martina SchembriCivil Engineering and Architecture Department, Università degli Studi di Pavia, Pavia, Italy.
Sonja JelicCivil Engineering and Architecture Department, Università degli Studi di Pavia, Pavia, Italy.
Alessandra FavilliVeterinary and Food Safety of Animal Origin Department, ATS Pavia, Pavia, Italy.
Daniele BissaccoSection of Vascular Surgery, Cardio Thoracic Vascular Department, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Maurizio DomaninSection of Vascular Surgery, Cardio Thoracic Vascular Department, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Joost A van HerwaardenDepartment of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
Ferdinando AuricchioCivil Engineering and Architecture Department, Università degli Studi di Pavia, Pavia, Italy.
Santi TrimarchiSection of Vascular Surgery, Cardio Thoracic Vascular Department, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
University of Pavia · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversity of Milan · ITUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The relationship among increased aortic arch angulation, aortic flow dynamics, and vessel wall stiffness remains unclear. This experimental ex vivo study investigated how increased aortic arch angulation affects aortic stiffness and stent-graft induced aortic stiffening, assessed by pulse wave velocity (PWV). Methods: Porcine thoracic aortas were connected to a circulatory mock loop in a Type I and Type III aortic arch configuration. Baseline characteristics and blood pressures were measured. Proximal and distal flow curves were acquired to calculate PWV in both arch configurations. After that, a thoracic stent-graft (VAMF2626C100TU) was deployed in aortas with adequate proximal landing zone diameters to reach 10% t0 20% oversizing. Acquisitions were repeated for both arch configurations after stent-graft deployment. Results: Twenty-four aortas were harvested, surgically prepared, and mounted. Cardiac output was kept constant for both arch configurations (Type I: 4.74 ± 0.40 and Type III: 4.72 ± 0.38 L/minute; Conclusions: Increased aortic arch angulation-as in a Type III arch-is associated with higher aortic PWV and blood pressures and this may negatively influence cardiovascular health.

Indexed as

aortic flow dynamicsarch angulationpulse wave velocityTEVARtype III aortic arch

Identifiers

PMID38420559
PMCPMC10897663
OpenAlexW4388840301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.