Evidence map›Paper›PMID 38420330›Full record

ArticleBiomedical optics express2023

Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy.

Joel Rodriguez Troncoso, Umme Marium Mim, Jesse D Ivers, Santosh K Paidi, Mason G Harper, Khue G Nguyen, Sruthi Ravindranathan, Lisa Rebello, David E Lee, David A Zaharoff and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Joel Rodriguez TroncosoDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR 72701, USA.
Umme Marium MimDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR 72701, USA.
Jesse D IversDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR 72701, USA.
Santosh K PaidiDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID https://orcid.org/0000-0002-7034-586X
Mason G HarperDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR 72701, USA.
Khue G NguyenDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR 72701, USA.
Sruthi RavindranathanDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR 72701, USA.
Lisa RebelloCell and Molecular Biology Program, University of Arkansas, Fayetteville, AR 72701, USA.
David E LeeCell and Molecular Biology Program, University of Arkansas, Fayetteville, AR 72701, USA.
David A ZaharoffJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Raleigh, NC 27695, USA.
Ishan BarmanDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Narasimhan RajaramDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR 72701, USA.ORCID https://orcid.org/0000-0003-1224-8567
University of Arkansas at Fayetteville · USJohns Hopkins University · USNorth Carolina State University · US

Funding

Unraveling Gene-Environment Interactions Shaping Metabolism: A Multi-Omics Analysis in DrosophilaP20GM139768 · NIGMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI Joanna Fiddler · 2021 to 2026
$17.0M
Determination of functional and molecular biomarkers of treatment resistance with multimodal optical spectroscopyR01CA238025 · NCI · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI RAJARAM, NARASIMHAN · 2019 to 2024
$2.0M
Next-generation optical nanoprobes: From quantum biosensing to cellular monitoringR35GM149272 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ISHAN BARMAN · 2023 to 2026
$1.6M
Development and testing of a clinically compatible multimodal spectroscopic probe for noninvasive sensing of tumor oxygenation and metabolism in oral cancerR15CA238861 · NCI · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI MULDOON, TIMOTHY J · 2020 to 2020
$419k
NCI NIH HHS R01 CA238025NCI NIH HHS R15 CA238861NIGMS NIH HHS P20 GM139768NIGMS NIH HHS R35 GM149272
6 · The paper itself

Abstract

We used diffuse reflectance spectroscopy to quantify tissue absorption and scattering-based parameters in similarly sized tumors derived from a panel of four isogenic murine breast cancer cell lines (4T1, 4T07, 168FARN, 67NR) that are each capable of accomplishing different steps of the invasion-metastasis cascade. We found lower tissue scattering, increased hemoglobin concentration, and lower vascular oxygenation in indolent 67NR tumors incapable of metastasis compared with aggressive 4T1 tumors capable of metastasis. Supervised learning statistical approaches were able to accurately differentiate between tumor groups and classify tumors according to their ability to accomplish each step of the invasion-metastasis cascade. We investigated whether the inhibition of metastasis-promoting genes in the highly metastatic 4T1 tumors resulted in measurable optical changes that made these tumors similar to the indolent 67NR tumors. These results demonstrate the potential of diffuse reflectance spectroscopy to noninvasively evaluate tumor biology and discriminate between indolent and aggressive tumors.

Identifiers

PMID38420330
PMCPMC10898562
OpenAlexW4387972810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.