Evidence map›Paper›PMID 38419627›Full record

ArticleFrontiers in microbiology2024

Immune cell early activation, apoptotic kinetic, and T-cell functional impairment in domestic pigs after ASFV CADC_HN09 strain infection.

Yunfei Tian, Dongyue Wang, Shicheng He, Zhen Cao, Wencai Li, Fei Jiang, Yifan Shi, Yuxin Hao, Xinhao Wei, Qingqing Wang and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Yunfei Tian *College of Veterinary Medicine, Institute of Comparative Medicine, Yangzhou University, Yangzhou, China.
Dongyue Wang *The Biosafety High-Level Laboratory Management Office, China Animal Disease Control Center, Beijing, China.
Shicheng HeAnimal Disease Control Center of Hunan Province, Changsha, China.
Zhen CaoThe Biosafety High-Level Laboratory Management Office, China Animal Disease Control Center, Beijing, China.
Wencai LiThe Biosafety High-Level Laboratory Management Office, China Animal Disease Control Center, Beijing, China.
Fei JiangThe Biosafety High-Level Laboratory Management Office, China Animal Disease Control Center, Beijing, China.
Yifan ShiThe Biosafety High-Level Laboratory Management Office, China Animal Disease Control Center, Beijing, China.
Yuxin HaoThe Biosafety High-Level Laboratory Management Office, China Animal Disease Control Center, Beijing, China.
Xinhao WeiThe Biosafety High-Level Laboratory Management Office, China Animal Disease Control Center, Beijing, China.
Qingqing WangThe Biosafety High-Level Laboratory Management Office, China Animal Disease Control Center, Beijing, China.
Shuai QieThe Biosafety High-Level Laboratory Management Office, China Animal Disease Control Center, Beijing, China.
Jiangtao WangThe Biosafety High-Level Laboratory Management Office, China Animal Disease Control Center, Beijing, China.
Ting LiThe Biosafety High-Level Laboratory Management Office, China Animal Disease Control Center, Beijing, China.
Xiaoli HaoCollege of Veterinary Medicine, Institute of Comparative Medicine, Yangzhou University, Yangzhou, China.
Jianzhong ZhuCollege of Veterinary Medicine, Institute of Comparative Medicine, Yangzhou University, Yangzhou, China.
Jiajun WuThe Biosafety High-Level Laboratory Management Office, China Animal Disease Control Center, Beijing, China.
Shaobin ShangCollege of Veterinary Medicine, Institute of Comparative Medicine, Yangzhou University, Yangzhou, China.
Xinyan ZhaiThe Biosafety High-Level Laboratory Management Office, China Animal Disease Control Center, Beijing, China.
China Animal Disease Control Center · CNYangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

African swine fever (ASF) caused by the African swine fever virus (ASFV) is a fatal and highly contagious disease of domestic pigs characterized by rapid disease progression and death within 2 weeks. How the immune cells respond to acute ASFV infection and contribute to the immunopathogenesis of ASFV has not been completely understood. In this study, we examined the activation, apoptosis, and functional changes of distinct immune cells in domestic pigs following acute infection with the ASFV CADC_HN09 strain using multicolor flow cytometry. We found that ASFV infection induced broad apoptosis of DCs, monocytes, neutrophils, and lymphocytes in the peripheral blood of pigs over time. The expression of MHC class II molecule (SLA-DR/DQ) on monocytes and conventional DCs as well as CD21 expression on B cells were downregulated after ASFV infection, implying a potential impairment of antigen presentation and humoral response. Further examination of CD69 and

Indexed as

apoptoticASFVcytokineimmunopathogenesisT cell early activation

Identifiers

PMID38419627
PMCPMC10899498
OpenAlexW4391818698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.