Evidence map›Paper›PMID 38419585›Full record

ArticleInterdisciplinary cardiovascular and thoracic surgery2024

Novel para-aortic cardiac assistance using a pre-stretched dielectric elastomer actuator.

Silje Ekroll Jahren, Thomas Martinez, Armando Walter, Francesco Clavica, Paul Philipp Heinisch, Eric Buffle, Markus Martin Luedi, Jürgen Hörer, Dominik Obrist, Thierry Carrel and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Interdisciplinary cardiovascular and thoracic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Silje Ekroll JahrenIntegrated Actuators Laboratory (LAI), École polytechnique fédérale de Lausanne (EPFL), Neuchâtel, Switzerland.ORCID 0000-0003-3931-5141
Thomas MartinezIntegrated Actuators Laboratory (LAI), École polytechnique fédérale de Lausanne (EPFL), Neuchâtel, Switzerland.ORCID 0000-0001-6366-1488
Armando WalterIntegrated Actuators Laboratory (LAI), École polytechnique fédérale de Lausanne (EPFL), Neuchâtel, Switzerland.ORCID 0000-0002-9812-8525
Francesco ClavicaIntegrated Actuators Laboratory (LAI), École polytechnique fédérale de Lausanne (EPFL), Neuchâtel, Switzerland.ORCID 0000-0002-8967-5877
Paul Philipp HeinischDepartment of Congenital and Pediatric Heart Surgery, German Heart Center Munich, Technical University of Munich, Munich, Germany.ORCID 0000-0003-4061-4499
Eric BuffleDepartment of Cardiology, Bern University Hospital Inselspital, University of Bern, Bern, Switzerland.ORCID 0000-0002-2396-5062
Markus Martin LuediDepartment of Anaesthesiology, Bern University Hospital Inselspital, University of Bern, Bern, Switzerland.ORCID 0000-0002-9049-2584
Jürgen HörerDepartment of Congenital and Pediatric Heart Surgery, German Heart Center Munich, Technical University of Munich, Munich, Germany.ORCID 0000-0002-0814-3474
Dominik ObristARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland.ORCID 0000-0002-6062-9076
Thierry CarrelDepartment of Cardiac Surgery, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-7881-6822
Yoan CivetIntegrated Actuators Laboratory (LAI), École polytechnique fédérale de Lausanne (EPFL), Neuchâtel, Switzerland.
Yves PerriardIntegrated Actuators Laboratory (LAI), École polytechnique fédérale de Lausanne (EPFL), Neuchâtel, Switzerland.ORCID 0000-0003-2350-4562
University of Bern · CHÉcole Polytechnique Fédérale de Lausanne · CHDeutsches Herzzentrum München · DEUniversity of Zurich · CH

Funding

Werner Siemens Stiftung
6 · The paper itself

Abstract

objectivesWe propose an evolution of a dielectric elastomer actuator-based cardiac assist device that acts as a counterpulsation system. We introduce a new pre-stretched actuator and implant the device in a graft bypass between the ascending and descending aorta to redirect all blood through the device (ascending aorta clamped). The objective was to evaluate the influence of these changes on the assistance provided to the heart.

methodsThe novel para-aortic device and the new implantation technique were tested in vivo in 5 pigs. We monitored the pressure and flow in the aorta as well as the pressure-volume characteristics of the left ventricle. Different activation timings were tested to identify the optimal device actuation.

resultsThe proposed device helps reducing the end-diastolic pressure in the aorta by up to 13 ± 4.0% as well as the peak systolic pressure by up to 16 ± 3.6%. The early diastolic pressure was also increased up to 10 ± 3.5%. With different activation, we also showed that the device could increase or decrease the stroke volume.

conclusionsThe new setup and the novel para-aortic device presented here helped improve cardiac assistance compared to previous studies. Moreover, we revealed a new way to assist the heart by actuating the device at different starting time to modify the left ventricular stroke volume and stroke work.

Indexed as

Cardiac assist deviceCounterpulsationDielectric elastomer actuatorin vivo experiment

Identifiers

PMID38419585
PMCPMC10955250
OpenAlexW4392287042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.