Evidence map›Paper›PMID 38419568›Full record

ArticleMovement disorders clinical practice2024

Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias.

Ruo-Yah Lai, Christian Rummey, Christian J Amlang, Chi-Ying R Lin, Tiffany X Chen, Susan Perlman, George Wilmot, Christopher M Gomez, Jeremy D Schmahmann, Henry Paulson and 19 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders clinical practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Treatment of primary adult-onset neurodegenerative cerebellar ataxias.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 3 countries.

Ruo-Yah LaiDepartment of Neurology, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0003-0371-583X
Christian RummeyClinical Data Science, Basel, Switzerland.
Christian J AmlangDepartment of Neurology, Columbia University Medical Center, New York, New York, USA.
Chi-Ying R LinAlzheimer's Disease and Parkinson's Disease Centers, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-9607-974X
Tiffany X ChenDepartment of Neurology, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0001-5443-0610
Susan PerlmanDepartment of Neurology, University of California Los Angeles, Los Angeles, California, USA.
George WilmotDepartment of Neurology, Emory University, Atlanta, Georgia, USA.
Christopher M GomezDepartment of Neurology, University of Chicago, Chicago, Illinois, USA.
Jeremy D SchmahmannAtaxia Center, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-0706-5125
Henry PaulsonDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Sarah H YingDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Chiadi U OnyikeDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Theresa A ZesiewiczDepartment of Neurology, University of South Florida, Tampa, Florida, USA.ORCID 0000-0002-7173-1666
Khalaf O BusharaDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
Michael D GeschwindDepartment of Neurology, University of California San Francisco, San Francisco, California, USA.
Karla P FigueroaDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
Stefan M PulstDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
Sub H SubramonyDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Matthew R BurnsDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Puneet OpalDepartment of Neurology, Northwestern University, Chicago, Illinois, USA.
Antoine DuquetteCentre Hospitalier de l'Université de Montréal, University of Montreal, Montreal, Quebec, Canada.
Tetsuo AshizawaHouston Methodist Research Institute, Houston, Texas, USA.ORCID 0000-0001-7180-2869
Ali G HamedaniDepartments of Neurology, Ophthalmology, and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Marie Y DavisDepartment of Neurology, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-2502-6293
Sharan R SrinivasanDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Lauren R MooreNational Ataxia Foundation, Minneapolis, Minnesota, USA.
Vikram G ShakkottaiDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Liana S RosenthalDepartment of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-5140-3967
Sheng-Han KuoDepartment of Neurology, Columbia University Medical Center, New York, New York, USA.
Johns Hopkins University · USColumbia University Irving Medical Center · USUniversity of Florida · USUniversity of Michigan · USUniversity of Utah · USBaylor College of Medicine · USCentre Hospitalier de l’Université de Montréal · CAEmory University · USHarvard University · USHouston Methodist · USNational Ataxia Foundation · USNorthwestern University · USSUNY Downstate Health Sciences University · USSwiss Data Science Center · CHThe University of Texas Southwestern Medical Center · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Chicago · USUniversity of Minnesota · USUniversity of Pennsylvania · US

Funding

Understanding the Cellular Basis of Movement DisordersR01NS082351 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Puneet Opal · 2013 to 2026
$6.2M
Targeting Cerebellar Endoplasmic Reticulum Calcium Handling in Essential TremorR01NS124854 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHYLLIS L FAUST, Sheng-Han Kuo · 2022 to 2026
$2.9M
Targeting Cerebellar Excitatory Synapses for Tremor ProgressionR01NS118179 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2020 to 2024
$2.2M
Cerebellar Circuitry in the Pathophysiology of TremorR01NS104423 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2018 to 2022
$2.0M
NIH HHS NINDS #R01 NS104423NIH HHS NINDS #R01 NS118179NIH HHS NINDS #R01 NS124854NINDS NIH HHS R01 NS082351NINDS NIH HHS R01 NS104423NINDS NIH HHS R01 NS118179NINDS NIH HHS R01 NS124854
6 · The paper itself

Abstract

backgroundFatigue is a prevalent and debilitating symptom in neurological disorders, including spinocerebellar ataxias (SCAs). However, the risk factors of fatigue in the SCAs as well as its impact have not been well investigated.

objectivesTo study the prevalence of fatigue in SCAs, the factors contributing to fatigue, and the influence of fatigue on quality of life.

methodsFatigue was assessed in 418 participants with SCA1, SCA2, SCA3, and SCA6 from the Clinical Research Consortium for the Study of Cerebellar Ataxia using the Fatigue Severity Scale. We conducted multi-variable linear regression models to examine the factors contributing to fatigue as well as the association between fatigue and quality of life.

resultsFatigue was most prevalent in SCA3 (52.6%), followed by SCA1 (36.7%), SCA6 (35.7%), and SCA2 (35.6%). SCA cases with fatigue had more severe ataxia and worse depressive symptoms. In SCA3, those with fatigue had a longer disease duration and longer pathological CAG repeat numbers. In multi-variable models, depressive symptoms, but not ataxia severity, were associated with more severe fatigue. Fatigue, independent of ataxia and depression, contributed to worse quality of life in SCA3 and SCA6 at baseline, and fatigue continued affecting quality of life throughout the disease course in all types of SCA.

conclusionsFatigue is a common symptom in SCAs and is closely related to depression. Fatigue significantly impacts patients' quality of life. Therefore, screening for fatigue should be considered a part of standard clinical care for SCAs.

Indexed as

FatigueQuality of LifeSpinocerebellar AtaxiasAdultAgedDepressionFemaleHumansMaleMiddle AgedPrevalenceSeverity of Illness Indexcerebellar ataxiacerebellumfatiguequality of lifespinocerebellar ataxia

Identifiers

PMID38419568
PMCPMC11078491
OpenAlexW4392287165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.