Evidence map›Paper›PMID 38419062›Full record

ArticleHead & face medicine2024

Exploring the association between PITX2, third molars agenesis and sella turcica morphology : PITX2, third molars agenesis and sella turcica morphology.

Erika Calvano Küchler, Jordanna de Melo Teixeira do Brasil, Isabela Ribeiro Madalena, Peter Proff, Flares Baratto-Filho, Mohammad Khursheed Alam, Angela Graciela Deliga Schroder, César Penazzo Lepri, Christian Kirschneck, Maria Angélica Hueb de Menezes-Oliveira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & face medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Erika Calvano KüchlerDepartment of Orthodontics, Medical Faculty, University Hospital Bonn, Welschnonnenstraße 17, 53111, Bonn, Germany. erikacalvano@gmail.com.
Jordanna de Melo Teixeira do BrasilDepartment of Biomaterials, University of Uberaba, Uberaba, Minas Gerais, Brazil, 38.055-500, Nenê Sabino, 1801.
Isabela Ribeiro MadalenaDepartment of Biomaterials, University of Uberaba, Uberaba, Minas Gerais, Brazil, 38.055-500, Nenê Sabino, 1801.
Peter ProffDepartment of Orthodontics, University of Regensburg, Regensburg, Germany, Franz-Josef-Strauß-Allee, 11, 93053.
Flares Baratto-FilhoSchool of Dentistry, Tuiuti University from Parana, Curitiba, Paraná, Brazil, Padre Ladislau Kula, 395, 82010-210.
Mohammad Khursheed AlamCollege of Dentistry, Jouf University, Al-Jouf, Saudi Arabia.
Angela Graciela Deliga SchroderSchool of Dentistry, Tuiuti University from Parana, Curitiba, Paraná, Brazil, Padre Ladislau Kula, 395, 82010-210.
César Penazzo LepriDepartment of Biomaterials, University of Uberaba, Uberaba, Minas Gerais, Brazil, 38.055-500, Nenê Sabino, 1801.
Christian KirschneckDepartment of Orthodontics, Medical Faculty, University Hospital Bonn, Welschnonnenstraße 17, 53111, Bonn, Germany.
Maria Angélica Hueb de Menezes-OliveiraDepartment of Biomaterials, University of Uberaba, Uberaba, Minas Gerais, Brazil, 38.055-500, Nenê Sabino, 1801.
Universidade de Uberaba · BRUniversidade Tuiuti do Paraná · BRUniversity Hospital Bonn · DEAl Jouf University · SAUniversity of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPITX2 is required for mammalian development and single nucleotide polymorphisms (SNPs) in this gene could be involved in dental agenesis and sella turcica patterns. Thus, the present study evaluated the association between SNPs in PITX2, third molars agenesis and sella turcica phenotypes. MATERIALS AND

methodsThe sample consisted of healthy orthodontic German patients with lateral cephalometric radiographs with clearly visualization of the sella turcica, and dental orthopantomograms. The morphological variations of the sella turcica were evaluated using the lateral cephalograms, while third molar agenesis was evaluated using orthopantomograms. DNA isolated from buccal cells was used for genotyping three SNPs in PITX2 (rs3796902, rs1947187, and rs2595110). The analyzes were performed using a significance of 5%. There was no association between third molar agenesis and sella turcica phenotypes (p > 0.05). SNPs in PITX2 were also not associated with third molars agenesis (p > 0.05).

resultsSNPs in PITX2 were associated with sella turcica phenotypes. The rs3796902 was associated with hypertrophic posterior clinoid process (p = 0.013). The rs1947187 and rs2595110 were associated with sella turcica bridge type A (p = 0.013 and p = 0.011, respectively for genotype distribution). Patients that carry the genotypes GG-CC-AG (rs3796902- rs1947187- rs2595110) had 7.2 higher chance to present sella turcica bridge type A (p = 0.002; Odds ratio = 7.2, Confidence interval 95% 2.04-27.04).

conclusionsThird molar agenesis was not associated with SNPs in PITX2 and sella turcica phenotypes. SNPs in PITX2 may have an important role in sella turcica pattern.

Indexed as

Molar, ThirdSella TurcicaCephalometryHomeobox Protein PITX2HumansMouth MucosaRadiography, PanoramicHomeobox Protein PITX2PITX2 protein, humanGeneSella turcicaTooth agenesis

Identifiers

PMID38419062
PMCPMC10900691
OpenAlexW4392239302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.