Evidence map›Paper›PMID 38419014›Full record

ArticleRespiratory research2024

Local heterogeneity of normal lung parenchyma and small airways disease are associated with COPD severity and progression.

Alexander J Bell, Ravi Pal, Wassim W Labaki, Benjamin A Hoff, Jennifer M Wang, Susan Murray, Ella A Kazerooni, Stefanie Galban, David A Lynch, Stephen M Humphries and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Alexander J BellDepartment of Radiology, University of Michigan, 109 Zina Pitcher Place BSRB A506, Ann Arbor, MI, 48109-2200, USA.
Ravi PalDepartment of Radiology, University of Michigan, 109 Zina Pitcher Place BSRB A506, Ann Arbor, MI, 48109-2200, USA.
Wassim W LabakiDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Benjamin A HoffDepartment of Radiology, University of Michigan, 109 Zina Pitcher Place BSRB A506, Ann Arbor, MI, 48109-2200, USA.
Jennifer M WangDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Susan MurraySchool of Public Health, University of Michigan, Ann Arbor, MI, USA.
Ella A KazerooniDepartment of Radiology, University of Michigan, 109 Zina Pitcher Place BSRB A506, Ann Arbor, MI, 48109-2200, USA.
Stefanie GalbanDepartment of Radiology, University of Michigan, 109 Zina Pitcher Place BSRB A506, Ann Arbor, MI, 48109-2200, USA.
David A LynchDepartment of Radiology, National Jewish Health, Denver, CO, USA.
Stephen M HumphriesDepartment of Radiology, National Jewish Health, Denver, CO, USA.
Fernando J MartinezWeill Cornell Medical College, New York, NY, USA.
Charles R HattImbio, LLC, Minneapolis, MN, USA.
MeiLan K HanDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Sundaresh Ram *Department of Radiology, University of Michigan, 109 Zina Pitcher Place BSRB A506, Ann Arbor, MI, 48109-2200, USA. sundarer@umich.edu.
Craig J Galban *Department of Radiology, University of Michigan, 109 Zina Pitcher Place BSRB A506, Ann Arbor, MI, 48109-2200, USA. cgalban@med.umich.edu.
University of Michigan–Ann Arbor · USNational Jewish Health · USCornell University · USImbio (United States) · US

Funding

PULMONARY CELLULAR AND MOLECULAR BIOLOGY TRAININGT32HL007749 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Robert Pickett Dickson · 1993 to 2026
$19.9M
Prediction of COPD Progression by PRMR01HL150023 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GALBAN, CRAIG J, HAN, MEILAN K · 2020 to 2023
$2.8M
An Early Imaging Marker of EmphysemaR01HL139690 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GALBAN, CRAIG J · 2019 to 2022
$1.9M
Defining Pathways in COPD Patient Oriented ResearchK24HL138188 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MeiLan K Han · 2017 to 2026
$1.2M
NHLBI NIH HHS K24 HL138188NHLBI NIH HHS R01 HL139690NHLBI NIH HHS R01 HL150023NHLBI NIH HHS T32 HL 007749
6 · The paper itself

Abstract

backgroundSmall airways disease (SAD) is a major cause of airflow obstruction in COPD patients and has been identified as a precursor to emphysema. Although the amount of SAD in the lungs can be quantified using our Parametric Response Mapping (PRM) approach, the full breadth of this readout as a measure of emphysema and COPD progression has yet to be explored. We evaluated topological features of PRM-derived normal parenchyma and SAD as surrogates of emphysema and predictors of spirometric decline.

methodsPRM metrics of normal lung (PRM

resultsMultivariable cross-sectional analysis of COPD subjects showed that V and χ measures for PRM

conclusionsWe demonstrated that V and χ of fSAD and Norm have independent value when associated with lung function and emphysema. In addition, we demonstrated that these readouts are predictive of spirometric decline when used as inputs in a ML model. Our topological PRM approach using PRM

Indexed as

EmphysemaPulmonary Disease, Chronic ObstructivePulmonary EmphysemaCross-Sectional StudiesForced Expiratory VolumeHumansLungChronic obstructive pulmonary diseaseComputed tomography of the chestEmphysemaMachine learningParametric response mappingSmall airways disease

Identifiers

PMID38419014
PMCPMC10903150
OpenAlexW4392240124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.