Evidence map›Paper›PMID 38418972›Full record

ArticleJournal of nanobiotechnology2024

Multifunctional biomimetic hydrogel dressing provides anti-infection treatment and improves immunotherapy by reprogramming the infection-related wound microenvironment.

Xiaogang Bao, Shicheng Huo, Zhenhua Wang, Shengyan Yang, Linyun Dou, Yifei Liu, Jian Huang, Chang Cai, Bin Fang, Guohua Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

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  15. Advances in Hydrogel-Based Drug Delivery Systems.Gels (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiaogang Bao *Department of Orthopedic Surgery, The Spine Surgical Center, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Shicheng Huo *Department of Orthopedic Surgery, The Spine Surgical Center, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China. waznxyz@126.com.
Zhenhua Wang *Department of Laboratory Medicine, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Shengyan YangDepartment of Pharmacy, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Linyun DouDepartment of Orthopedic Surgery, The Spine Surgical Center, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Yifei LiuDepartment of Orthopedic Surgery, The Spine Surgical Center, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Jian HuangDepartment of Orthopedic Surgery, The Spine Surgical Center, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Chang CaiDepartment of Orthopedic Surgery, The Spine Surgical Center, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Bin FangDepartment of Orthopedics, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310000, China. fangbin008@outlook.com.
Guohua XuDepartment of Orthopedic Surgery, The Spine Surgical Center, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China. xuguohuamail@smmu.edu.cn.
Second Military Medical University · CNZhejiang Chinese Medical University · CN

Funding

National Natural Foundation of China 82272533Shanghai Sailing Program 21YF1458200
6 · The paper itself

Abstract

The advancement of biomaterials with antimicrobial and wound healing properties continues to present challenges. Macrophages are recognized for their significant role in the repair of infection-related wounds. However, the interaction between biomaterials and macrophages remains complex and requires further investigation. In this research, we propose a new sequential immunomodulation method to enhance and expedite wound healing by leveraging the immune properties of bacteria-related wounds, utilizing a novel mixed hydrogel dressing. The hydrogel matrix is derived from porcine acellular dermal matrix (PADM) and is loaded with a new type of bioactive glass nanoparticles (MBG) doped with magnesium (Mg-MBG) and loaded with Curcumin (Cur). This hybrid hydrogel demonstrates controlled release of Cur, effectively eradicating bacterial infection in the early stage of wound infection, and the subsequent release of Mg ions (Mg

Indexed as

Anti-Infective AgentsCurcuminWound InfectionAnimalsAnti-Bacterial AgentsBandagesBiocompatible MaterialsBiomimeticsHydrogelsImmunotherapySwineWound HealingAnti-Bacterial AgentsAnti-Infective AgentsBiocompatible MaterialsCurcuminHydrogelsBioactive glass nanoparticlesCurcuminImmunomodulationInfection-associated woundsMagnesium

Identifiers

PMID38418972
PMCPMC10902999
OpenAlexW4392230543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.