Evidence map›Paper›PMID 38418917›Full record

ArticleNature2024

On the genetic basis of tail-loss evolution in humans and apes.

Bo Xia, Weimin Zhang, Guisheng Zhao, Xinru Zhang, Jiangshan Bai, Ran Brosh, Aleksandra Wudzinska, Emily Huang, Hannah Ashe, Gwen Ellis and 10 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
20.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
  2. Article
  3. A putativebioRxiv : the preprint server for biology · 2026
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  8. Review
  9. Article
  10. Special Issue "Repetitive DNA".International journal of molecular sciences · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Genomics Insights Into High-Latitude Adaptation of Tibetan Macaques.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 2 countries.

Bo XiaInstitute for Computational Medicine, NYU Langone Health, New York, NY, USA. xiabo@broadinstitute.org.ORCID 0000-0003-0929-7253
Weimin Zhang *Institute for Systems Genetics, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-8836-1438
Guisheng Zhao *Institute for Computational Medicine, NYU Langone Health, New York, NY, USA.
Xinru Zhang *Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-0633-2888
Jiangshan BaiGene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ran BroshInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.ORCID 0000-0001-9714-8623
Aleksandra WudzinskaInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-3143-7673
Emily HuangInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Hannah AsheInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Gwen EllisInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Maayan PourInstitute for Computational Medicine, NYU Langone Health, New York, NY, USA.
Yu ZhaoInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.ORCID 0000-0003-4659-9832
Camila CoelhoInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Yinan ZhuInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Alexander MillerDepartment of Neuroscience and Physiology, NYU Langone Health, New York, NY, USA.
Jeremy S DasenDepartment of Neuroscience and Physiology, NYU Langone Health, New York, NY, USA.
Matthew T MauranoInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-2218-8628
Sang Y KimDepartment of Pathology, NYU Langone Health, New York, NY, USA.
Jef D BoekeInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA. Jef.Boeke@nyulangone.org.ORCID 0000-0001-5322-4946
Itai YanaiInstitute for Computational Medicine, NYU Langone Health, New York, NY, USA. Itai.Yanai@nyulangone.org.ORCID 0000-0002-8438-2741
Institute for Systems Biology · USNYU Langone Health · USBroad Institute · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
Somatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI John M Sedivy · 2016 to 2026
$30.4M
Supplement for Center for Synthetic Regulatory Genomics: Building CACNA1C alleles associated with Neuropsychiatric DisordersRM1HG009491 · NHGRI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jef D BOEKE · 2018 to 2026
$20.9M
Genetic Control of Circuit Assembly in the Vertebrate Spinal Cord - Diversity SupplementR35NS116858 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JEREMY S DASEN · 2020 to 2026
$6.7M
TRAINING PROGRAM IN DEVELOPMENTAL GENETICS.T32HD007520 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TREISMAN, JESSICA E · 1999 to 2023
$3.9M
Genomic organization of long-distance gene regulationR35GM119703 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MAURANO, MATTHEW THOMAS · 2016 to 2020
$2.1M
Transposable Element Interaction and Its Impact on Human Development and HealthDP5OD033430 · OD · BROAD INSTITUTE, INC. · PI XIA, BO · 2022 to 2025
$1.9M
NCI NIH HHS P30 CA016087NHGRI NIH HHS RM1 HG009491NIA NIH HHS P01 AG051449NICHD NIH HHS T32 HD007520NIGMS NIH HHS R35 GM119703NIH HHS DP5 OD033430NINDS NIH HHS R35 NS116858
6 · The paper itself

Abstract

The loss of the tail is among the most notable anatomical changes to have occurred along the evolutionary lineage leading to humans and to the 'anthropomorphous apes'

Indexed as

Alternative SplicingEvolution, MolecularHominidaeTailT-Box Domain ProteinsAlu ElementsAnimalsBrachyury ProteinDisease Models, AnimalExonsGenomeHumansIntronsMiceNeural Tube DefectsPhenotypeBrachyury ProteinProtein IsoformsT-Box Domain ProteinsTBXT protein, human

Identifiers

PMID38418917
PMCPMC10901737
OpenAlexW4392231439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.