Evidence map›Paper›PMID 38418914›Full record

ArticleNature2024

Symmetry breaking and chiral amplification in prebiotic ligation reactions.

Min Deng, Jinhan Yu, Donna G Blackmond

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Origin of Single-Molecule Reaction Chirality.Research (Washington, D.C.) · 2026
    Article
  11. Article
  12. Life's homochirality: Across a prebiotic network.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Stereoselectivity of Aminoacyl-RNA Loop-Closing Ligation.Journal of the American Chemical Society · 2025
    Article
  17. Article
  18. Article
  19. Autocatalytic symmetry breaking and chiral amplification in a feedback network combining amino acid synthesis and ligation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Min DengDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID 0000-0002-8256-7240
Jinhan YuDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.
Donna G BlackmondDepartment of Chemistry, Scripps Research, La Jolla, CA, USA. blackmond@scripps.edu.ORCID 0000-0001-9829-8375

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The single chirality of biological molecules is a signature of life. Yet, rationalizing how single chirality emerged remains a challenging goal

Indexed as

BiopolymersEvolution, ChemicalPeptidesProteinsStereoisomerismNucleic AcidsOrigin of LifeSolubilityBiopolymersNucleic AcidsPeptidesProteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.