ArticleNature2024
Compartmentalized ocular lymphatic system mediates eye-brain immunity.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
23.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Role of meningeal lymphatic vessels in brain homeostasis.Frontiers in immunology · 2025Pooled it
- Article
- Ocular-brain co-immunotherapy targeting amyloid-beta in Alzheimer's disease: Challenges and promising therapeutic avenues.Neural regeneration research · 2026Article
- Putative mechanisms of ocular inflammation in syphilis.Journal of ophthalmic inflammation and infection · 2026Review
- Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases.Translational neurodegeneration · 2026Review
- Brain barriers at the crossroads of glioma immune surveillance and immunotherapy response.Nature reviews. Cancer · 2026Review
- Infection control in the brain and the eye.Acta ophthalmologica · 2026Review
- Smart Nanodelivery for Eye-Brain Disorders: Synergistic CCL2 Neutralization and MMP9 Silencing Reverse Anxiety in High Myopia.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Macular choriocapillaris perfusion area: a potential biomarker of mild cognitive impairment in patients with cerebral small vessel disease.Stroke and vascular neurology · 2026Observational
- Disruption of the brain-spleen axis impairs monocyte-microglia communication and accelerates disease progression in a mouse model of amyloidosis.Nature communications · 2026Article
- Optic nerve cerebrospinal fluid drainage via lymphatic vessels in its sheath.NPJ microgravity · 2026Article
- Ocular Lymphatics in Health and Disease.Diagnostics (Basel, Switzerland) · 2026Review
- Microglia-independent rAAV-induced inflammation causes persistent ocular immune dysregulation rescued by S1P receptor modulation.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Transcriptomic and Neuroimaging Decoding of Brain-Immune Crosstalk in Thyroid Eye Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tissue resident memory T cells populate the human uveal tract.Scientific reports · 2026Article
- Vitreoretinal Myeloid Cell Heterogeneity: Diverse Roles in Homeostasis, Immune Surveillance, and Pathophysiology.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Macrophage immunosenescence prolongs intraocular inflammation in aged mice via impaired induction of regulatory T cells.bioRxiv : the preprint server for biology · 2026Article
- Time-Resolved Oxidative Stress and Apoptosis in Murine Retina under Acute Hypobaric Hypoxia with Parallel Activation of the LIF-JAK-STAT3 Axis.Molecular neurobiology · 2026Article
- Advances in Optical Tissue Clearing for Three-Dimensional Ocular Imaging and Analysis.Journal of ophthalmology · 2026Review
- Principles of resident tissue macrophages revealed by the eye.Advances in immunology · 2026Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 6 institutions in 3 countries.
Xiangyun Yin *Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT, USA.
Sophia Zhang *Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0009-0003-6412-9305
Ju Hyun Lee *Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT, USA.ORCID 0000-0001-6728-2071
Huiping DongDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
George MourgkosDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Gordon TerwilligerSection of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.
Aurora KrausCenter of Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, USA.
Luiz Henrique GeraldoDepartment of Internal Medicine, Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3318-4697
Mathilde PouletDepartment of Internal Medicine, Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-2216-4132
Suzanne FischerDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Ting ZhouDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8783-8380
Farrah Shalima MohammedDepartment of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT, USA.
Jiangbing ZhouDepartment of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT, USA.ORCID 0000-0002-1201-5360
Yongfu WangStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0000-0003-3499-0586
Seth MalloyStowers Institute for Medical Research, Kansas City, MO, USA.
Nicolas RohnerStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0000-0003-3248-2772
Lokesh SharmaSection of Pulmonary and Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3040-9029
Irene SalinasCenter of Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, USA.
Anne EichmannDepartment of Internal Medicine, Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA.
Jean-Leon ThomasDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3397-0292
W Mark SaltzmanDepartment of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT, USA.ORCID 0000-0002-2163-549X
Anita HuttnerDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Caroline ZeissDepartment of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.
Aaron RingDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3699-2446
Akiko IwasakiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7824-9856
Eric SongDepartment of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT, USA. eric.song@yale.edu.ORCID 0000-0001-5448-5865
Yale University · USStowers Institute for Medical Research · USUniversity of New Mexico · USHoward Hughes Medical Institute · USInserm · FRWestlake University · CN
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1MPoly(amine-co-ester)s for targeted delivery of gene editing agents to treat cystic fibrosis in animal models: SCGE Disease Models Studies SupplementUH3HL147352 · NHLBI · YALE UNIVERSITY · PI GLAZER, PETER M, SALTZMAN, W. MARK · 2021 to 2022
$2.4MRole of meningeal lymphatic vasculature in neuroimmune communication developmentR01NS130057 · NINDS · YALE UNIVERSITY · PI Anne Christine Eichmann, AKIKO IWASAKI · 2023 to 2026
$2.1MNCATS NIH HHS UL1 TR001863NHLBI NIH HHS UH3 HL147352NIDDK NIH HHS P30 DK034989NINDS NIH HHS R01 NS130057
Abstract
The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected in the eye, particularly in the retina
Indexed as
BrainEyeLymphatic SystemAnimalsBacteriaDependovirusFemaleGlioblastomaHerpesvirus 2, HumanHumansIntravitreal InjectionsLymphatic VesselsMacaca mulattaMaleMeningesMiceVascular Endothelial Growth Factor C
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.