Evidence map›Paper›PMID 38418876›Full record

ArticleNature2024

Multisensory gamma stimulation promotes glymphatic clearance of amyloid.

Mitchell H Murdock, Cheng-Yi Yang, Na Sun, Ping-Chieh Pao, Cristina Blanco-Duque, Martin C Kahn, TaeHyun Kim, Nicolas S Lavoie, Matheus B Victor, Md Rezaul Islam and 15 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06644573 (Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia), which is not on this map. Cited by 213 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
213citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06644573 phase1not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia

TypeinterventionalSponsorNyree PennRan2025 to 2026Enrolled100ConditionsChronic Insomnia, Sleep Deprivation, REM Behavior Disorder, REM Sleep Behavior DisorderArmsPROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca, Continuous EEG Monitoring
3 · Its place in the literature

Who cites it

213 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  5. Gamma sensory stimulation in mild Alzheimer's dementia: An open-label extension study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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153 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Mitchell H MurdockDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Cheng-Yi YangDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Na SunMIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.
Ping-Chieh PaoDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-6788-7185
Cristina Blanco-DuqueDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Martin C KahnDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
TaeHyun KimDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nicolas S LavoieDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Matheus B VictorDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Md Rezaul IslamDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Fabiola GalianaDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0009-0006-8926-496X
Noelle LearyDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Sidney WangDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Adele BubnysDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Emily MaDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Leyla A AkayDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-5944-2466
Madison SneveDepartments of Biological Engineering and Brain and Cognitive Sciences, McGovern Institute, Cambridge, MA, USA.
Yong QianDepartments of Biological Engineering and Brain and Cognitive Sciences, McGovern Institute, Cambridge, MA, USA.
Cuixin LaiSchool of Life Sciences, Westlake University, Westlake Laboratory of Life Sciences and Biomedicine, and Westlake Institute for Advanced Study, Hangzhou, China.ORCID 0000-0003-4257-4013
Michelle M McCarthyDepartment of Mathematics and Statistics, Boston University, Boston, MA, USA.
Nancy KopellDepartment of Mathematics and Statistics, Boston University, Boston, MA, USA.
Manolis KellisMIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.ORCID 0000-0001-7113-9630
Kiryl D PiatkevichDepartments of Biological Engineering and Brain and Cognitive Sciences, McGovern Institute, Cambridge, MA, USA.
Edward S BoydenDepartments of Biological Engineering and Brain and Cognitive Sciences, McGovern Institute, Cambridge, MA, USA.
Li-Huei TsaiDepartment of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA. lhtsai@mit.edu.ORCID 0000-0003-1262-0592

Funding

Novel Platforms for Systematic Optical Control of Complex Neural Circuits In VivoR01DA029639 · NIDA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2010 to 2023
$6.7M
The Cdk5/p35 KinaseR01NS051874 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TSAI, LI-HUEI · 2006 to 2015
$3.7M
High-Performance Imaging Through Scattering Living TissueR01DA045549 · NIDA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2017 to 2020
$3.5M
Multidimensional Optimization of Voltage Indicators for In Vivo Neural Activity ImagingR01MH122971 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HAN, XUE · 2020 to 2024
$3.4M
The Cdk5/35 KinaseR37NS051874 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TSAI, LI-HUEI · 2016 to 2022
$3.2M
Noninvasive sensory stimulation to promote glymphatic-lymphatic clearance for the treatment of Alzheimer’s DiseaseR01AT011460 · NCCIH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TSAI, LI-HUEI · 2021 to 2025
$3.0M
Manipulating Neural Oscillations with Non-Invasive Sensory Stimulation for Alzheimer's Disease InterventionR01AG069232 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TSAI, LI-HUEI · 2022 to 2025
$2.8M
RNA Scaffolds for Cell Specific Multiplexed Neural ObservationR01MH114031 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2017 to 2020
$2.8M
NCCIH NIH HHS R01 AT011460NIA NIH HHS R01 AG069232NIDA NIH HHS R01 DA029639NIDA NIH HHS R01 DA045549NIMH NIH HHS R01 MH114031NIMH NIH HHS R01 MH122971NINDS NIH HHS R01 NS051874NINDS NIH HHS R37 NS051874
6 · The paper itself

Abstract

The glymphatic movement of fluid through the brain removes metabolic waste

Indexed as

Alzheimer DiseaseAmyloidBrainCerebrospinal FluidExtracellular FluidGamma RhythmGlymphatic SystemAnimalsAquaporin 4AstrocytesCerebral CortexDisease Models, AnimalElectric StimulationInterneuronsMiceVasoactive Intestinal PeptideAmyloidAqp4 protein, mouseAquaporin 4Vasoactive Intestinal Peptide

Identifiers

PMID38418876
PMCPMC10917684

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.