Evidence map›Paper›PMID 38418836›Full record

ArticleScientific reports2024

Date fruit melanin is primarily based on (-)-epicatechin proanthocyanidin oligomers.

Muneeba Zubair Alam, Clinton Emeka Okonkwo, João P Cachaneski-Lopes, Carlos F O Graeff, Augusto Batagin-Neto, Saeed Tariq, Sabu Varghese, Matthew J O'Connor, Abuzar E Albadri, J Beau W Webber and 3 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Muneeba Zubair AlamDepartment of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, P.O. Box: 15551, Al-Ain, United Arab Emirates.
Clinton Emeka OkonkwoDepartment of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, P.O. Box: 15551, Al-Ain, United Arab Emirates.
João P Cachaneski-LopesPostgraduate Program in Materials Science and Technology (POSMAT), São Paulo State University (UNESP), Bauru, SP, Brazil.
Carlos F O GraeffPostgraduate Program in Materials Science and Technology (POSMAT), São Paulo State University (UNESP), Bauru, SP, Brazil.
Augusto Batagin-NetoPostgraduate Program in Materials Science and Technology (POSMAT), São Paulo State University (UNESP), Bauru, SP, Brazil.
Saeed TariqDepartment of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Sabu VargheseCore Technology Platforms, New York University Abu Dhabi, 129188, Abu Dhabi, United Arab Emirates.
Matthew J O'ConnorCore Technology Platforms, New York University Abu Dhabi, 129188, Abu Dhabi, United Arab Emirates.
Abuzar E AlbadriDepartment of Chemistry, College of Science, Qassim University, 51452, Buraidah, Saudi Arabia.
J Beau W WebberLab-Tools Ltd., Marlowe Innovation Centre, Marlowe Way, Ramsgate, CT12 6FA, UK.
Mohammed TariqueDepartment of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, P.O. Box: 15551, Al-Ain, United Arab Emirates.
Mutamed AyyashDepartment of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, P.O. Box: 15551, Al-Ain, United Arab Emirates.
Afaf Kamal-EldinDepartment of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, P.O. Box: 15551, Al-Ain, United Arab Emirates. afaf.kamal@uaeu.ac.ae.
United Arab Emirates University · AEUniversidade Estadual Paulista (Unesp) · BRNew York University Abu Dhabi · AEQassim University · SA

Funding

Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES) . 88887.802762/2023-00 CAPES-PrIntBrazilian Coordination for the Improvement of Higher Education Personnel (CAPES) . (grants 88887.817519/2023-00 CAPES-Proex)United Arab Emirates University 12R158
6 · The paper itself

Abstract

Plant-based melanin seems to be abundant, but it did not receive scientific attention despite its importance in plant biology and medicinal applications, e.g. photoprotection, radical scavenging, antimicrobial properties, etc. Date fruit melanin (DM) has complex, graphene-like, polymeric structure that needs characterization to understand its molecular properties and potential applications. This study provides the first investigation of the possible molecular composition of DM. High performance size-exclusion chromatography (HPSEC) suggested that DM contains oligomeric structures (569-3236 Da) and transmission electron microscopy (TEM) showed agglomeration of these structures in granules of low total porosity (10-1000 Å). Nuclear magnetic resonance (NMR) spectroscopy provided evidence for the presence of oligomeric proanthocyanidins and electron paramagnetic resonance (EPR) spectroscopy revealed a g-factor in the range 2.0034-2.005. Density functional theory (DFT) calculations suggested that the EPR signals can be associated with oligomeric proanthocyanidin structures having 4 and above molecular units of (-)-epicatechin. The discovery of edible melanin in date fruits and its characterization are expected to open a new area of research on its significance to nutritional and sensory characteristics of plant-based foods.

Indexed as

CatechinPhoeniceaeProanthocyanidinsFruitMelaninsCatechinMelaninsproanthocyanidinProanthocyanidinsDate fruit(−)-EpicatechinMelaninPhoenix dactylifera L.Proanthocyanidins

Identifiers

PMID38418836
PMCPMC10901811
OpenAlexW4392233752

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.