ArticleScientific reports2024
The spatiotemporal trend of human brucellosis in China and driving factors using interpretability analysis.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Systematic Review and Meta-Analysis on the Prevalence of Brucella melitensis in Sheep and Goat.Veterinary medicine and science · 2025Pooled it
- Dynamic Modeling of Prevention and Control ofTransboundary and emerging diseases · 2025Pooled it
- Brucellosis seroprevalence in cattle in China during 2014-2024: a systematic review and meta-analysis.Emerging microbes & infections · 2024Pooled it
- Spatiotemporal Analysis of the Primary Factors and Risk Quantification of Human Brucellosis Prevention and Control in Zhejiang Province of China.Zoonoses and public health · 2026Article
- Brucellosis in the One Health Context: Gaps in Diagnosis, Control, and Global Epidemiology.Journal of epidemiology and global health · 2026Review
- Comparative production of recombinant capripoxvirus in Vero cells using microcarrier- and macrocarrier-based dynamic cell culture systems under serum-free conditions.Applied microbiology and biotechnology · 2026Article
- Epidemiological analysis of infectious disease in border port areas of Heilongjiang Province, 2014-2023.BMC public health · 2026Article
- Spatiotemporal dynamics and environmental factors of human brucellosis in mainland China, 2004-2022.BMC infectious diseases · 2026Article
- Establishment of a rapid Brucella detection method based on MCDA-CRISPR dual signal amplification system for reducing transfusion-transmitted diseases.Scientific reports · 2026Article
- Socioeconomic drivers of human Brucellosis in Ningxia, China: A one health and spatiotemporal analysis for targeted intervention.PLoS neglected tropical diseases · 2026Article
- Metagenomic Next-Generation Sequencing in Brucellar Spondylitis with Discordant Serologic Findings in a Non-Endemic Region: A Case Report and Literature Review.Infection and drug resistance · 2026Article
- Brucellosis in healthcare settings: research advances in nosocomial infection prevention and control.Frontiers in public health · 2026Review
- Spatiotemporal distribution characteristics and disease burden of human brucellosis in Inner Mongolia Autonomous Region, 2014-2023.Frontiers in public health · 2026Article
- Integration of single-cell and bulk RNA sequencing reveals divergent T-cell immune circuits and a shared osteo-immune pathway in spinal tuberculosis and brucellar spondylitis.Frontiers in cellular and infection microbiology · 2026Article
- Human-animal interfaces and zoonotic disease risks in China: a review of contact behaviors and risk communication.Science in One Health · 2026Review
- Spatiotemporal epidemiological characteristics of human brucellosis in Henan Province, from 1956 to 2023.BMC public health · 2025Article
- Genome phylogenetic analysis of Brucella melitensis in Northwest China.BMC microbiology · 2025Article
- Risk effects of environmental factors on human brucellosis in Aksu Prefecture, Xinjiang, China, 2014-2023.Scientific reports · 2025Article
- Intrauterine fetal death due to Brucella melitensis infection: a case report and literature review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Review
- Meteorological, Socioeconomic, and Environmental Factors Influencing Human Brucellosis Occurrence in Yunnan, China, 2006-2021: A Bayesian Spatiotemporal Modeling Study.Transboundary and emerging diseases · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
Human brucellosis has reemerged in China, with a distinct change in its geographical distribution. The incidence of human brucellosis has significantly risen in inland regions of China. To gain insights into epidemic characteristics and identify factors influencing the geographic spread of human brucellosis, our study utilized the Extreme Gradient Boosting (XGBoost) algorithm and interpretable machine learning techniques. The results showed a consistent upward trend in the incidence of human brucellosis, with a significant increase of 8.20% from 2004 to 2021 (95% CI: 1.70, 15.10). The northern region continued to face a serious human situation, with a gradual upward trend. Meanwhile, the western and southern regions have experienced a gradual spread of human brucellosis, encompassing all regions of China over the past decade. Further analysis using Shapley Additive Explanations (SHAP) demonstrated that higher Gross Domestic Product (GDP) per capita and increased funding for education have the potential to reduce the spread. Conversely, the expansion of human brucellosis showed a positive correlation with bed availability per 1000 individuals, humidity, railway mileage, and GDP. These findings strongly suggest that socioeconomic factors play a more significant role in the spread of human brucellosis than other factors.
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