Evidence map›Paper›PMID 38418535›Full record

ArticleNature chemistry2024

Genetically encoded bioorthogonal tryptophan decaging in living cells.

Yuchao Zhu, Wenlong Ding, Yulin Chen, Ye Shan, Chao Liu, Xinyuan Fan, Shixian Lin, Peng R Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Click-Triggered Bioorthogonal Bond-Cleavage Reactions.Topics in current chemistry (Cham) · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yuchao Zhu *New Cornerstone Science Laboratory, Synthetic and Functional Biomolecules Center, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.ORCID 0009-0001-1795-8667
Wenlong Ding *Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.ORCID 0000-0001-9681-2027
Yulin ChenZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.ORCID 0000-0001-6174-1580
Ye ShanNew Cornerstone Science Laboratory, Synthetic and Functional Biomolecules Center, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Chao LiuZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Xinyuan FanNew Cornerstone Science Laboratory, Synthetic and Functional Biomolecules Center, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, China. xinyuanfan@pku.edu.cn.ORCID 0000-0002-3099-8495
Shixian LinZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China. sxlin@zju.edu.cn.ORCID 0000-0001-9718-9986
Peng R ChenNew Cornerstone Science Laboratory, Synthetic and Functional Biomolecules Center, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, China. pengchen@pku.edu.cn.ORCID 0000-0002-0402-7417
Peking University · CNShaoxing University · CNZhejiang University · CN

Funding

China Postdoctoral Science Foundation BX20200005Chinese Ministry of Science and Technology | Department of S and T for Social Development (Department of S&T for Social Development) 2019YFA09006600Chinese Ministry of Science and Technology | Department of S and T for Social Development (Department of S&T for Social Development) 2019YFA0904201, 2022YFA1304700Chinese Ministry of Science and Technology | Department of S and T for Social Development (Department of S&T for Social Development) 2021YFA1302603National Natural Science Foundation of China (National Science Foundation of China) 21937001, 22137001, 91753000National Natural Science Foundation of China (National Science Foundation of China) 22207005National Natural Science Foundation of China (National Science Foundation of China) 22207095National Natural Science Foundation of China (National Science Foundation of China) 22222701, 22077004, 92253301National Natural Science Foundation of China (National Science Foundation of China) 22222705, 92253302Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) Z200010
6 · The paper itself

Abstract

Tryptophan (Trp) plays a critical role in the regulation of protein structure, interactions and functions through its π system and indole N-H group. A generalizable method for blocking and rescuing Trp interactions would enable the gain-of-function manipulation of various Trp-containing proteins in vivo, but generating such a platform remains challenging. Here we develop a genetically encoded N

Indexed as

ProteinsTryptophanSignal TransductionProteinsTryptophan

Identifiers

PMID38418535
OpenAlexW4392233829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.