Evidence map›Paper›PMID 38418462›Full record

ArticleNature communications2024

Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G

Zoe Köck, Kilian Schnelle, Margherita Persechino, Simon Umbach, Hannes Schihada, Dovile Januliene, Kristian Parey, Steffen Pockes, Peter Kolb, Volker Dötsch and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Journal of the American Chemical Society · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cell-free protein synthesis platforms for accelerating drug discovery.Biotechnology notes (Amsterdam, Netherlands) · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Zoe Köck *Centre for Biomolecular Magnetic Resonance, Institute for Biophysical Chemistry, Goethe-University of Frankfurt/Main, Frankfurt, Germany.
Kilian Schnelle *Department of Biology/Chemistry, Structural Biology section, University of Osnabrück, Osnabrück, Germany.ORCID 0000-0001-8808-594X
Margherita PersechinoDepartment of Pharmaceutical Chemistry, University of Marburg, Marburg, Germany.ORCID 0000-0003-1539-7621
Simon UmbachCentre for Biomolecular Magnetic Resonance, Institute for Biophysical Chemistry, Goethe-University of Frankfurt/Main, Frankfurt, Germany.
Hannes SchihadaDepartment of Pharmaceutical Chemistry, University of Marburg, Marburg, Germany.
Dovile JanulieneDepartment of Biology/Chemistry, Structural Biology section, University of Osnabrück, Osnabrück, Germany.ORCID 0000-0002-3279-7590
Kristian PareyDepartment of Biology/Chemistry, Structural Biology section, University of Osnabrück, Osnabrück, Germany.ORCID 0000-0002-4842-6479
Steffen PockesInstitute of Pharmacy, University of Regensburg, Regensburg, Germany.ORCID 0000-0002-2211-9868
Peter KolbDepartment of Pharmaceutical Chemistry, University of Marburg, Marburg, Germany.ORCID 0000-0003-4089-614X
Volker DötschCentre for Biomolecular Magnetic Resonance, Institute for Biophysical Chemistry, Goethe-University of Frankfurt/Main, Frankfurt, Germany.ORCID 0000-0001-5720-212X
Arne MöllerDepartment of Biology/Chemistry, Structural Biology section, University of Osnabrück, Osnabrück, Germany. arne.moeller@uni-osnabrueck.de.ORCID 0000-0003-1101-5366
Daniel HilgerDepartment of Pharmaceutical Chemistry, University of Marburg, Marburg, Germany. daniel.hilger@pharmazie.uni-marburg.de.ORCID 0000-0001-5179-1357
Frank BernhardCentre for Biomolecular Magnetic Resonance, Institute for Biophysical Chemistry, Goethe-University of Frankfurt/Main, Frankfurt, Germany. fbern@bpc.uni-frankfurt.de.ORCID 0000-0002-4860-1783
Goethe University Frankfurt · DEOsnabrück University · DEPhilipps University of Marburg · DEUniversity of Regensburg · DE

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) BE1911/9-1
6 · The paper itself

Abstract

Here we describe the cryo-electron microscopy structure of the human histamine 2 receptor (H

Indexed as

Escherichia coliHistamineCryoelectron MicroscopyHEK293 CellsHumansReceptors, Histamine H2HistamineReceptors, Histamine H2

Identifiers

PMID38418462
PMCPMC10901899
OpenAlexW4392241538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.