ArticleInternational journal of oral science2024
The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats.
Article in International journal of oral science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Rapid maxillary expansion related sutural and dentoalveolar changes provoke early-term oxidative stress.BMC oral health · 2026Trial
- In Vivo Assessment of SED: A Novel Biomechanical Indicator for Periodontal Tissue Remodeling in Clear Aligner Therapy.Annals of biomedical engineering · 2026Article
- Effects of testosterone and high-dose anabolic steroids on orthodontic-induced bone remodeling and root resorption: An animal study.Journal of periodontology · 2026Article
- Comparative evaluation of oral misoprostol and low-level laser therapy in orthodontic tooth movement in a rat model.BMC oral health · 2026Article
- Mechanical activation of Piezo1 promotes osteoclastogenesis in orthodontic tooth movement.BMC oral health · 2026Article
- Force-Dependent Presence of Senescent Cells Expressing Vascular Endothelial Growth Factor During Orthodontic Tooth Movement.Biology · 2026Article
- Development of a rat model for prophylactic free gingival graft to mitigate orthodontic-related alveolar bone fenestration/dehiscence.Frontiers in bioengineering and biotechnology · 2026Article
- Additive Manufactured Magnetoelectric Wireless Retainer as the Periodontal Remodeler for Post-Orthodontic Tissue Reconstruction and Relapse-Inhibition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Shaping Orthodontics of the Future: Concepts and Implications from a Cellular and Molecular Perspective.International journal of molecular sciences · 2025Review
- Synergistic effects of high-frequency vibration and orthodontic force on osteoclast numbers and root resorption in a rat model.The Angle orthodontist · 2025Article
- NADProgress in orthodontics · 2025Article
- Finite element analysis in the Dental Sciences: A Bibliometric and a Visual Study.International dental journal · 2025Article
- Expert consensus on the clinical strategies for orthodontic treatment with clear aligners.International journal of oral science · 2025Review
- The Interaction Between Orthodontics and Periodontal Tissue Remodeling :.Galen medical journal · 2025Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
The utilization of optimal orthodontic force is crucial to prevent undesirable side effects and ensure efficient tooth movement during orthodontic treatment. However, the sensitivity of existing detection techniques is not sufficient, and the criteria for evaluating optimal force have not been yet established. Here, by employing 3D finite element analysis methodology, we found that the apical distal region (A-D region) of mesial roots is particularly sensitive to orthodontic force in rats. Tartrate-resistant acidic phosphatase (TRAP)-positive osteoclasts began accumulating in the A-D region under the force of 40 grams (g), leading to alveolar bone resorption and tooth movement. When the force reached 80 g, TRAP-positive osteoclasts started appearing on the root surface in the A-D region. Additionally, micro-computed tomography revealed a significant root resorption at 80 g. Notably, the A-D region was identified as a major contributor to whole root resorption. It was determined that 40 g is the minimum effective force for tooth movement with minimal side effects according to the analysis of tooth movement, inclination, and hyalinization. These findings suggest that the A-D region with its changes on the root surface is an important consideration and sensitive indicator when evaluating orthodontic forces for a rat model. Collectively, our investigations into this region would aid in offering valuable implications for preventing and minimizing root resorption during patients' orthodontic treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.