Evidence map›Paper›PMID 38418452›Full record

ArticleNature communications2024

Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting.

Yasuo Kubota, Xiaorong Gu, Laila Terkawi, Juraj Bodo, Bartlomiej P Przychodzen, Hussein Awada, Nakisha Williams, Carmelo Gurnari, Naomi Kawashima, Mai Aly and 11 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 3 countries.

Yasuo KubotaDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-7909-5422
Xiaorong GuDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Laila TerkawiDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Juraj BodoDepartment of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA.
Bartlomiej P PrzychodzenDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Hussein AwadaDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-1445-7947
Nakisha WilliamsDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Carmelo GurnariDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Naomi KawashimaDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-9914-739X
Mai AlyDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Arda DurmazDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Minako MoriDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0003-4274-8714
Ben PonvilawanDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-0157-7720
Tariq KewanDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0003-4651-5125
Waled BahajDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Manja MeggendorferMLL Munich Leukemia Laboratory, Munich, Germany.ORCID 0000-0002-9038-3265
Babal K JhaDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-7660-5255
Valeria VisconteDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Heesun J RogersDepartment of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0001-8491-224X
Torsten HaferlachMLL Munich Leukemia Laboratory, Munich, Germany.ORCID 0000-0003-0196-2837
Jaroslaw P MaciejewskiDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA. maciejj@ccf.org.ORCID 0000-0002-6837-4346
Cleveland Clinic · USMunich Leukemia Laboratory (Germany) · DEUniversity of Rome Tor Vergata · IT

Funding

Therapeutic Implications of Molecular Defects in Bone Marrow FailureR35HL135795 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MACIEJEWSKI, JAROSLAW P. · 2017 to 2023
$5.7M
Eltombopag: Novel Mode of Action on Normal and Aplastic Anemia Hematopoietic Stem CellsR01DK131923 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Babal K Jha, Jaroslaw P. Maciejewski · 2022 to 2026
$3.3M
Targeting TET DNA Dioxygenases as Therapeutic Principle in Myeloid NeoplasmsR01CA257544 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI JHA, BABAL K, MACIEJEWSKI, JAROSLAW P. · 2021 to 2025
$3.0M
NCI NIH HHS R01 CA257544NHLBI NIH HHS R35 HL135795NIDDK NIH HHS R01 DK131923
6 · The paper itself

Abstract

PHF6 mutations (PHF6

Indexed as

Leukemia, Myeloid, AcuteNeoplasmsCore Binding Factor Alpha 2 SubunitFemaleHumansMaleMutationProteomicsRepressor ProteinsCore Binding Factor Alpha 2 SubunitPHF6 protein, humanRepressor Proteins

Identifiers

PMID38418452
PMCPMC10901781
OpenAlexW4392242454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.