Evidence map›Paper›PMID 38418414›Full record

ArticleThe British journal of nutrition2024

Glycine supplementation can partially restore oxidative stress-associated glutathione deficiency in ageing cats.

Avika Ruparell, Janet E Alexander, Ryan Eyre, Laura Carvell-Miller, Y Becca Leung, Samantha J M Evans, Lucy J Holcombe, Martina Heer, Phillip Watson

Open access · hybridAbstract read
In one paragraph

Article in The British journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Avika RuparellWaltham Petcare Science Institute, Melton Mowbray, Leicestershire, UK.ORCID 0000-0001-7141-7928
Janet E AlexanderWaltham Petcare Science Institute, Melton Mowbray, Leicestershire, UK.
Ryan EyreRoyal Canin Pet Health and Nutrition Centre, 6574 State Route 503N, Lewisburg, OH, USA.
Laura Carvell-MillerWaltham Petcare Science Institute, Melton Mowbray, Leicestershire, UK.
Y Becca LeungRoyal Canin Research & Development Center, Aimargues, France.
Samantha J M EvansThe Ohio State University, 1925 Coffey Rd, Columbus, OH, USA.
Lucy J HolcombeWaltham Petcare Science Institute, Melton Mowbray, Leicestershire, UK.
Martina HeerWaltham Petcare Science Institute, Melton Mowbray, Leicestershire, UK.ORCID 0000-0001-5534-911X
Phillip WatsonWaltham Petcare Science Institute, Melton Mowbray, Leicestershire, UK.
Bouygues (France) · FRThe Ohio State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracellular levels of glutathione, the major mammalian antioxidant, are reported to decline with age in several species. To understand whether ageing affects circulating glutathione levels in cats, blood was sampled from two age groups, < 3 years and > 9 years. Further, to determine whether dietary supplementation with glutathione precursor glycine (GLY) affects glutathione concentrations in senior cats (> 8 years), a series of free GLY inclusion level dry diets were fed. Subsequently, a 16-week GLY feeding study was conducted in senior cats (> 7 years), measuring glutathione, and markers of oxidative stress. Whole blood and erythrocyte total, oxidised and reduced glutathione levels were significantly decreased in senior cats, compared with their younger counterparts (

Indexed as

AgingDietary SupplementsErythrocytesGlutathioneGlycineOxidative StressAnimal FeedAnimalsAntioxidantsBiomarkersCatsDietDinoprostFemaleMaleAntioxidantsBiomarkersDinoprostGlutathioneGlycineAmino acidAntioxidantFelineSenior

Identifiers

PMID38418414
PMCPMC11361917
OpenAlexW4392291200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.