Evidence map›Paper›PMID 38417549›Full record

Trial reportThe Journal of nutrition2024

Preconception Micronutrient Supplementation Affects Maternal BMI and Body Composition Postpartum: A Randomized Controlled Trial in Vietnam.

Usha Ramakrishnan, Sonia Tandon Wimalasena, Melissa F Young, Long Q Khuong, Lan M Tran, Daniel J Hoffman, Reynaldo Martorell, Phuong H Nguyen

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01665378 (Impact of Pre-Pregnancy Micronutrient Supplementation on Maternal and Child Outcomes), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01665378 nacompletednot on this map

Impact of Pre-Pregnancy Micronutrient Supplementation on Maternal and Child Outcomes

TypeinterventionalSponsorEmory UniversityRan2011 to 2019Enrolled5,011ConditionsAnemia, Intrauterine Growth Retardation, Preterm Delivery, Iron DeficiencyArmsMultiple Micronutrient, Iron and Folic Acid, Folic Acid
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Usha RamakrishnanHubert Department of Global Health, Emory University, Atlanta, GA, United States; Doctoral Program in Nutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta GA, United States. Electronic address: uramakr@emory.edu.
Sonia Tandon WimalasenaDoctoral Program in Nutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta GA, United States.
Melissa F YoungHubert Department of Global Health, Emory University, Atlanta, GA, United States; Doctoral Program in Nutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta GA, United States.
Long Q KhuongHanoi University of Public Health, Hanoi, Vietnam.
Lan M TranDoctoral Program in Nutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta GA, United States.
Daniel J HoffmanDepartment of Nutritional Sciences, Program in International Nutrition, New Jersey Institute for Food, Nutrition, and Health, Center for Childhood Nutrition Research, Rutgers, the State University of New Jersey, New Brunswick, NJ, United States.
Reynaldo MartorellHubert Department of Global Health, Emory University, Atlanta, GA, United States; Doctoral Program in Nutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta GA, United States.
Phuong H NguyenThai Nguyen University of Pharmacy and Medicine, Thai Nguyen, Vietnam; Poverty, Health, and Nutrition Division, International Food Policy Research Institute, Washington, DC, United States.
Emory University · USHanoi University · VNInternational Food Policy Research Institute · USRutgers, The State University of New Jersey · US

Funding

Maternal and offspring FADS polymorphisms, dietary LC-PUFAs, and adolescent cardiometabolic healthF31HD106748 · NICHD · EMORY UNIVERSITY · PI TANDON, SONIA · 2022 to 2023
$72k
NICHD NIH HHS F31 HD106748
6 · The paper itself

Abstract

backgroundAlthough there is growing evidence on the role of preconception nutrition for birth outcomes, limited evidence exists for its effects on maternal health.

objectivesThis study evaluates the impact of preconception micronutrient supplementation on maternal BMI (kg/m

methodsWe followed females who participated in a randomized controlled trial of preconception supplementation in Vietnam and delivered live offspring (n = 1599). Females received weekly supplements containing either 2800 μg folic acid (FA) only, 60 mg iron and 2800 μg FA (IFA), or multiple micronutrients (MMs) (15 micronutrients including IFA) from baseline until conception followed by daily prenatal IFA supplements until delivery. Height, weight, mid-upper arm circumference, triceps skinfold, and waist-hip circumference were measured at recruitment and at 1, 2, and 6 to 7 y PP. Body fat was assessed using bioelectric impedance at 6 to 7 y PP (n = 867). Group comparisons were made using analysis of variance or chi-square tests and general linear models for adjusted models.

resultsAt 6 to 7 y PP, we found significant differences (P < 0.05) by treatment group for mean percent fat (MM: 29.2%; IFA: 27.6%; FA: 27.8%), absolute fat mass (MM: 15.1 kg; IFA: 14.0 kg; FA: 14.3 kg), and prevalence of underweight based on BMI < 18.5 (MM: 5.8%; IFA: 10.3%; FA: 14.3%). Mean BMI and triceps skinfold thickness were higher in the MM group, but these differences were not statistically significant; the differences in absolute fat mass were also attenuated after controlling for body weight. No differences were observed for fat-free mass, prevalence of overweight (BMI >23), or other anthropometric measurements.

conclusionsPreconception MM supplementation was associated with lower prevalence of underweight and higher percent fat when compared with IFA and/or FA only. Preconception micronutrient interventions may have long-term effects on maternal health and merit further examination. This trial was registered at clinicaltrials.gov as NCT01665378.

Indexed as

IronThinnessBody CompositionBody Mass IndexDietary SupplementsFemaleFolic AcidHumansMicronutrientsPostpartum PeriodPregnancyVietnamFolic AcidIronMicronutrientsmaternal body compositionmultiple micronutrientpreconceptionrandomized controlled trialVietnam

Identifiers

PMID38417549
PMCPMC11347800
OpenAlexW4392161200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.