Evidence map›Paper›PMID 38417435›Full record

ArticleNeuron2024

Transient cAMP production drives rapid and sustained spiking in brainstem parabrachial neurons to suppress feeding.

Jonnathan Singh Alvarado, Andrew Lutas, Joseph C Madara, Jeremiah Isaac, Caroline Lommer, Crystian Massengill, Mark L Andermann

Open access · greenAbstract read
In one paragraph

Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jonnathan Singh AlvaradoDivision of Endocrinology, Metabolism, and Diabetes, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Andrew LutasDivision of Endocrinology, Metabolism, and Diabetes, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA; Diabetes, Endocrinology, and Obesity Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: andrew.lutas@nih.gov.
Joseph C MadaraDivision of Endocrinology, Metabolism, and Diabetes, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Jeremiah IsaacDiabetes, Endocrinology, and Obesity Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Caroline LommerDivision of Endocrinology, Metabolism, and Diabetes, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Crystian MassengillProgram in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.
Mark L AndermannDivision of Endocrinology, Metabolism, and Diabetes, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. Electronic address: manderma@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USNational Institutes of Health · USHarvard University · US

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI HU, FRANK B · 1992 to 2021
$25.0M
Viral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MARGARET S LIVINGSTONE · 1998 to 2026
$21.3M
Neuromodulatory mechanisms underlying vagus nerve stimulation therapy for Alzheimer's diseaseDP1AT010971 · NCCIH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ANDERMANN, MARK L · 2019 to 2023
$6.6M
Investigating appetite control by G protein-coupled receptorsZIADK075169 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI LUTAS, ANDREW · 2022 to 2025
$3.2M
Compartmentalized molecular signaling in neural circuits controlling appetiteZIADK075167 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI LUTAS, ANDREW · 2022 to 2025
$3.1M
Neuromodulator signals regulating cue-induced feedingZIADK075168 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI LUTAS, ANDREW · 2022 to 2025
$3.1M
Neural Pathway Linking Nutritional State To Food-Cue Responses In Insular CortexR01DK109930 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ANDERMANN, MARK L · 2016 to 2020
$2.2M
Roles of cortical neuromodulation and offline reactivation in memory consolidation of emotionally salient visual experiencesR01MH123431 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ANDERMANN, MARK L · 2021 to 2025
$1.8M
Hunger modulation of food cue responses in amygdala by dopamine and ghrelinF32DK112589 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LUTAS, ANDREW · 2017 to 2019
$121k
SOCIAL INFLUENCES ON NEURAL PLASTICITYF32MH012343 · NIMH · UNIVERSITY OF WASHINGTON · PI WENNSTROM, KIRA L · 1999 to 2001
$46k
Intramural NIH HHS ZIA DK075169NCCIH NIH HHS DP1 AT010971NEI NIH HHS P30 EY012196NIDDK NIH HHS F32 DK112589NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK109930NIMH NIH HHS F32 MH012343NIMH NIH HHS R01 MH123431
6 · The paper itself

Abstract

Brief stimuli can trigger longer-lasting brain states. G-protein-coupled receptors (GPCRs) could help sustain such states by coupling slow-timescale molecular signals to neuronal excitability. Brainstem parabrachial nucleus glutamatergic (PBN

Indexed as

Action PotentialsCyclic AMPFeeding BehaviorNeuronsParabrachial NucleusAnimalsBrain StemCyclic AMP-Dependent Protein KinasesFemaleGlutamic AcidMaleMiceMice, Inbred C57BLOptogeneticsCyclic AMPCyclic AMP-Dependent Protein KinasesGlutamic Acidbrain slice imagingcalcium imagingcAMPelectrophysiologyfeedingfluorescent biosensor imagingGPCRin vivolickingneuronal activityparabrachial nucleusprotein kinase Atwo-photon microscopy

Identifiers

PMID38417435
PMCPMC11065603
OpenAlexW4392203152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.