Evidence map›Paper›PMID 38417321›Full record

ReviewCurrent opinion in chemical biology2024

D-Amino acid oxidase-derived chemogenetic oxidative stress: Unraveling the multi-omic responses to in vivo redox stress.

Fotios Spyropoulos, Thomas Michel

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Fotios SpyropoulosDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, USA. Electronic address: fspyropoulos@bwh.harvard.edu.
Thomas MichelCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 02115, USA. Electronic address: thomas_michel@hms.harvard.edu.
Brigham and Women's Hospital · US

Funding

TRAINING PROGRAM IN HYPERTENSIONT32HL007609 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ADLER, GAIL KURR · 1985 to 2022
$10.2M
Chemogenetic Neurovascular Oxidative Stress: Neurodegeneration and Cardiac RemodelingR01NS131182 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Thomas Michel · 2024 to 2026
$2.3M
Hydrogen peroxide in endothelial function and dysfunctionR01HL152173 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHEL, THOMAS · 2021 to 2024
$2.2M
Dynamic tissue-specific modulation of redox stress using chemogeneticsR33HL157918 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHEL, THOMAS · 2021 to 2022
$1.0M
Oxidative Stress and Mitochondrial Dysfunction in Chemogenetic Heart FailureK08HL168240 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Fotios Spyropoulos · 2023 to 2026
$735k
Chemogenetic approaches to define the roles of redox dysfunction in the cardiomyopathy of agingR21AG063073 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHEL, THOMAS · 2019 to 2020
$480k
NHLBI NIH HHS K08 HL168240NHLBI NIH HHS R01 HL152173NHLBI NIH HHS R33 HL157918NHLBI NIH HHS T32 HL007609NIA NIH HHS R21 AG063073NINDS NIH HHS R01 NS131182
6 · The paper itself

Abstract

Chemogenetic approaches have been developed to define the mechanisms whereby the intracellular oxidant hydrogen peroxide (H

Indexed as

Hydrogen PeroxideMultiomicsAmino AcidsAnimalsOxidation-ReductionOxidative StressProteomicsAmino AcidsHydrogen PeroxideAnimal modelsHeart failureNeurodegenerationOxidative stressReactive oxygen speciesTransgenic mice

Identifiers

PMID38417321
PMCPMC10957096
OpenAlexW4392214971

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.