Evidence map›Paper›PMID 38417222›Full record

ArticleNeoplasia (New York, N.Y.)2024

Identification of recurrent BRAF non-V600 mutations in intraductal carcinoma of the prostate in Chinese populations.

Jing Hu, Xinyi Chen, Feifei Sun, Lili Liu, Long Liu, Zimeng Yang, Hanwen Zhang, Zeyuan Yu, Ru Zhao, Yueyao Wang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neoplasia (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Jing HuDepartment of Pathology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Xinyi ChenDepartment of Pathology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Medical Group) Qingdao, Shandong, China; The Key Laboratory of Experimental Teratology, Ministry of Education and Department of Pathology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Feifei SunDepartment of Pathology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Lili LiuDepartment of Pathology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Medical Group) Qingdao, Shandong, China.
Long LiuDepartment of Pathology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Zimeng YangDepartment of Taekwondo, Art, Design, & Physical Education, Chosun University, Gwangju, Republic of Korea.
Hanwen ZhangThe Key Laboratory of Experimental Teratology, Ministry of Education and Department of Pathology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Zeyuan YuThe Key Laboratory of Experimental Teratology, Ministry of Education and Department of Pathology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Ru ZhaoDepartment of Pathology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Yueyao WangThe Key Laboratory of Experimental Teratology, Ministry of Education and Department of Pathology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Hui LiuDepartment of Pathology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Xiaorong YangClinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Fusheng SunDepartment of Pathology, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Bo HanDepartment of Pathology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China; The Key Laboratory of Experimental Teratology, Ministry of Education and Department of Pathology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. Electronic address: boh@sdu.edu.cn.
Qilu Hospital of Shandong University · CNShandong University · CNShandong Provincial QianFoShan Hospital · CNChosun University · KRQingdao University · CNUniversity of Michigan · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While BRAF alterations have been established as a driver in various solid malignancies, the characterization of BRAF alterations in prostate cancer (PCa) has not been thoroughly interrogated. By bioinformatics analysis, we first found that BRAF alterations were associated with advanced PCa and exhibited mutually exclusive pattern with ERG alteration across multiple cohorts. Of the most interest, recurrent non-V600 BRAF mutations were found in 3 of 21 (14.3 %) PCa patients demonstrating IDC-P morphology. Furthermore, experimental overexpression of BRAF

Indexed as

Carcinoma, Intraductal, NoninfiltratingProstatic NeoplasmsProto-Oncogene Proteins B-rafChinaHumansMaleMutationProstateBRAF protein, humanProto-Oncogene Proteins B-rafBRAF mutationIntraductal carcinoma of the prostate (IDC-P)prostate cancer (PCa)

Identifiers

PMID38417222
PMCPMC10904907
OpenAlexW4392214432

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.