Evidence map›Paper›PMID 38417122›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

On-Site Melanoma Diagnosis Utilizing a Swellable Microneedle-Assisted Skin Interstitial Fluid Sampling and a Microfluidic Particle Dam for Visual Quantification of S100A1.

Gaobo Wang, Yuyue Zhang, Hoi Kwan Kwong, Mengjia Zheng, Jianpeng Wu, Chenyu Cui, Kannie W Y Chan, Chenjie Xu, Ting-Hsuan Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. A Machine Vision Perspective on Droplet-Based Microfluidics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Swellable Microneedles in Drug Delivery and Diagnostics.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Gaobo WangDepartment of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, 999077, China.ORCID 0000-0002-4594-1635
Yuyue ZhangDepartment of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, 999077, China.
Hoi Kwan KwongDepartment of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, 999077, China.
Mengjia ZhengDepartment of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, 999077, China.
Jianpeng WuDepartment of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, 999077, China.
Chenyu CuiDepartment of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, 999077, China.
Kannie W Y ChanDepartment of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, 999077, China.
Chenjie XuDepartment of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, 999077, China.ORCID 0000-0002-8278-3912
Ting-Hsuan ChenDepartment of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, 999077, China.ORCID 0000-0003-4517-7750
City University of Hong Kong · HKDepartment of Health · CN

Funding

City University of Hong Kong 7020072City University of Hong Kong 9678242Research Grants Council, University Grants Committee CityU11100323Research Grants Council, University Grants Committee CityU11200820Research Grants Council, University Grants Committee CityU11217820Research Grants Council, University Grants Committee N_CityU118/20Shenzhen Fundamental Research and Discipline Layout project JCYJ20210324134006017
6 · The paper itself

Abstract

Malignant melanoma (MM) is the most aggressive form of skin cancer. The delay in treatment will induce metastasis, resulting in a poor prognosis and even death. Here, a two-step strategy for on-site diagnosis of MM is developed based on the extraction and direct visual quantification of S100A1, a biomarker for melanoma. First, a swellable microneedle is utilized to extract S100A1 in skin interstitial fluid (ISF) with minimal invasion. After elution, antibody-conjugated magnetic microparticles (MMPs) and polystyrene microparticles (PMPs) are introduced. A high expression level of S100A1 gives rise to a robust binding between MMPs and PMPs and reduces the number of free PMPs. By loading the reacted solution into the device with a microfluidic particle dam, the quantity of free PMPs after magnetic separation is displayed with their accumulation length inversely proportional to S100A1 levels. A limit of detection of 18.7 ng mL

Indexed as

Extracellular FluidMelanomaNeedlesS100 ProteinsSkin NeoplasmsAnimalsBiomarkers, TumorDisease Models, AnimalHumansMiceMicrofluidicsSkinBiomarkers, TumorS100A1 proteinS100 Proteinsinterstitial fluidmalignant melanomamicrofluidicsS100A1swellable microneedle

Identifiers

PMID38417122
PMCPMC11040363
OpenAlexW4392229679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.