ArticleScience translational medicine2024
Endothelial cells drive organ fibrosis in mice by inducing expression of the transcription factor SOX9.
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Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43citing papers in PubMed
19.3field-weighted citation impact, top 1% of its field
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Who cites it
43 citing papers in PubMed, 48 citations in OpenAlex.
- Reconstructing AF-associated atrial fibrosis: Patient-specific iPSC models, fit-for-purpose atrial microphysiological systems, and nanomedicine.Materials today. Bio · 2026Review
- Cardiac fibroblast diversity in HFpEF: states, niches, interorgan drivers and targets.Nature reviews. Cardiology · 2026Review
- 7th International Workshop on SOX Transcription Factors.Biology open · 2026Article
- Article
- Human single-cell atlas of proliferative diabetic retinopathy reveals a SOX15-overexpressing stromal population driving retinal fibrosis through the endothelin-1 -EDNRB axis.Journal of translational medicine · 2026Article
- High mobility group motif proteins' role in fibrosis, inflammation, and vascular injury in systemic sclerosis.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Targeting the Hippo pathway in pulmonary arterial hypertension: emerging pharmacological strategies.Journal of hypertension · 2026Review
- Review
- Review
- From Heterogeneity to Plasticity: Endothelial Dynamics in Lung Disease.Pulmonary circulation · 2026Review
- Tuft cells shape airway remodeling by eliciting OXGR1- and SOX9-dependent stem cell programs.Nature communications · 2026Article
- Single cell atlas decodes the molecular dynamics of scar repair after human rotator cuff tear.Bone research · 2026Article
- The Endothelial Cell Perspective in Pulmonary Fibrosis: From Cell Fate Decisions, Intercellular Communication, and EndoMT to Emerging Therapies.Canadian respiratory journal · 2026Review
- Dynamic activation and dual roles of SOX9Frontiers in cell and developmental biology · 2026Article
- The normal human lymph node cell classification and landscape defined by high-dimensional spatial proteomics.PloS one · 2026Article
- von Willebrand Factor: An Unhealthy Bond between Lung Endothelium and Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2025Article
- Capillary Endothelial Cells as Therapeutic Target in Pressure Overload-Induced Heart Failure.JACC. Basic to translational science · 2025Article
- Inhibition of Scarb1 on Endothelial Cells Attenuates Pressure Overload-Induced Heart Failure Progression.JACC. Basic to translational science · 2025Article
- Microtubules and mechanosensing: key players in endothelial responses to mechanical stimuli.Cellular and molecular life sciences : CMLS · 2025Review
- Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor-Stroma Ratio and Promote Cancer Progression.Cancer research · 2025Article
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Authors and funding
29 authors at 7 institutions in 2 countries.
Felix A TrogischECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0002-3513-4362
Aya AbouissaECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0002-8325-0296
Merve KelesECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0002-5212-3753
Anne BirkeECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.ORCID 0009-0009-4080-8809
Manuela FuhrmannECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
Gesine M DittrichECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0002-9053-078X
Nina WeinzierlECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
Elvira WinkECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
Julio CorderoDZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, 68167 Mannheim, Germany.
Adel ElsherbinyECAS, Department of Cardiovascular Genomics and Epigenomics, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
Abel Martin-GarridoECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
Steve GreinECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0002-4095-7830
Shruthi HemannaECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0001-7934-2801
Ellen HofmannECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
Luka NicinInstitute for Cardiovascular Regeneration, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany.
Sofia-Iris BibliCardiopulmonary Institute, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany.ORCID 0000-0001-7153-6628
Rannar AirikInstitute of Molecular Biology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-7055-6325
Andreas KispertInstitute of Molecular Biology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-8154-0257
Ralf KistSchool of Dental Sciences, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4BW, UK.ORCID 0000-0003-3729-5693
Sun QuanchaoMedical Research Center, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
Sina W KürschnerDepartment of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, 68167 Mannheim, Germany.ORCID 0000-0002-4546-9684
Manuel WinklerDepartment of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, 68167 Mannheim, Germany.ORCID 0000-0003-2415-9350
Norbert GretzMedical Research Center, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
Carolin MoglerInstitute of Pathology, School of Medicine, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0003-3400-7254
Thomas KorffECAS, Adjunct Faculty, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.
Philipp-Sebastian KochDepartment of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, 68167 Mannheim, Germany.ORCID 0000-0001-5236-0516
Stefanie DimmelerInstitute for Cardiovascular Regeneration, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany.ORCID 0000-0002-1045-2436
Gergana DobrevaDZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, 68167 Mannheim, Germany.ORCID 0000-0002-4814-9416
Joerg HeinekeECAS (European Center for Angioscience), Department of Cardiovascular Physiology, Mannheim Faculty of Medicine, Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0002-1541-3030
University of Mannheim · DETechnische Hochschule Mannheim · DEGoethe University Frankfurt · DEHeidelberg University · DEMedizinische Hochschule Hannover · DENewcastle Dental Hospital · GBTechnical University of Munich · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibrosis is a hallmark of chronic disease. Although fibroblasts are involved, it is unclear to what extent endothelial cells also might contribute. We detected increased expression of the transcription factor
Indexed as
Heart FailureTranscription FactorsAnimalsDisease Models, AnimalEndothelial CellsFibrosisHumansIntercellular Signaling Peptides and ProteinsLiver CirrhosisMiceSOX9 Transcription FactorIntercellular Signaling Peptides and ProteinsSOX9 protein, humanSox9 protein, mouseSOX9 Transcription FactorTranscription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.