Evidence map›Paper›PMID 38416718›Full record

ArticleJournal of neurophysiology2024

Temporal and region-specific tau hyperphosphorylation in the medulla and forebrain coincides with development of functional changes in male obese Zucker rats.

Paromita Das-Earl, Derek A Schreihofer, Nathalie Sumien, Ann M Schreihofer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Paromita Das-EarlDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Derek A SchreihoferDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, United States.ORCID 0000-0001-5566-7628
Nathalie SumienDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, United States.ORCID 0000-0002-0077-9873
Ann M SchreihoferDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States.ORCID 0000-0003-0069-2847
University of North Texas · US

Funding

Mechanisms for impaired short-term control of blood pressure with obesityR01HL132568 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI SCHREIHOFER, ANN M · 2017 to 2020
$1.8M
NHLBI NIH HHS R01 HL132568
6 · The paper itself

Abstract

Metabolic syndrome (MetS) is associated with development of tauopathies that contribute to cognitive decline. Without functional leptin receptors, male obese Zucker rats (OZRs) develop MetS, and they have increased phosphorylated tau (ptau) with impaired cognitive function. In addition to regulating energy balance, leptin enhances activation of the hippocampus, which is essential for spatial learning and memory. Whether spatial learning and memory are always impaired in OZRs or develop with MetS is unknown. We hypothesized that male OZRs develop MetS traits that promote regional increases in ptau and functional deficits associated with those brain regions. In the medulla and cortex, tau-pSer

Indexed as

HypertensionMetabolic SyndromeAnimalsDisease Models, AnimalHippocampusInsulinLeptinMaleObesityPhosphatidylinositol 3-KinasesProsencephalonRatsRats, ZuckerReceptors, LeptinInsulinLeptinPhosphatidylinositol 3-KinasesReceptors, LeptinAlzheimer’s diseasearterial pressure telemetryinsulin signalingmetabolic syndromeMorris water maze

Identifiers

PMID38416718
PMCPMC11305650
OpenAlexW4392242686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.