Evidence map›Paper›PMID 38416374›Full record

ReviewNeurochemical research2024

The Role of Neuromodulation and Potential Mechanism in Regulating Heterotopic Ossification.

Dengju Li, Changxing Liu, Haojue Wang, Yunfeng Li, Yaqi Wang, Senbo An, Shui Sun

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurochemical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dengju LiShandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Changxing LiuShandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Haojue WangShandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Yunfeng LiShandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Yaqi WangShandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Senbo AnShandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. ansenbo@sdfmu.edu.cn.
Shui SunShandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. sunshui@sdfmu.edu.cn.
Shandong First Medical University · CNShandong University · CN

Funding

National Natural Science Foundation of China 82102600National Natural Science Foundation of China 82272485
6 · The paper itself

Abstract

Heterotopic ossification (HO) is a pathological process characterized by the aberrant formation of bone in muscles and soft tissues. It is commonly triggered by traumatic brain injury, spinal cord injury, and burns. Despite a wide range of evidence underscoring the significance of neurogenic signals in proper bone remodeling, a clear understanding of HO induced by nerve injury remains rudimentary. Recent studies suggest that injury to the nervous system can activate various signaling pathways, such as TGF-β, leading to neurogenic HO through the release of neurotrophins. These pathophysiological changes lay a robust groundwork for the prevention and treatment of HO. In this review, we collected evidence to elucidate the mechanisms underlying the pathogenesis of HO related to nerve injury, aiming to enhance our understanding of how neurological repair processes can culminate in HO.

Indexed as

Ossification, HeterotopicAnimalsHumansNeurotransmitter AgentsSignal TransductionNeurotransmitter AgentsHeterotopic ossificationNerve injuryNeuromodulationNeurotrophic factorsTGF-β

Identifiers

PMID38416374
OpenAlexW4392233699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.