Evidence map›Paper›PMID 38416335›Full record

ArticleApplied biochemistry and biotechnology2024

Characterization, Anti-glycation, Anti-inflammation, and Lipase Inhibitory Properties of Rauvolfia vomitoria Leaf Extract: In Vitro and In Silico Evaluations for Obesity Treatment.

Akpovwehwee A Anigboro, Oghenetega J Avwioroko, Omoerere Oborirhovo, Onoriode Akeghware, Ernest U Durugbo, Augustine Apiamu, Victor I Olaoye, Uchechukwu S Ezealigo, Nyerhovwo J Tonukari

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Article in Applied biochemistry and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Akpovwehwee A AnigboroDepartment of Biochemistry, Faculty of Science, Delta State University, P.M.B.001, Abraka, Nigeria. akposanigboro@yahoo.co.uk.
Oghenetega J AvwiorokoDepartment of Biochemistry, Faculty of Basic Medical Sciences, Redeemer's University, Ede, Osun State, Nigeria. joavwioroko@gmail.com.ORCID http://orcid.org/0000-0001-8742-6765
Omoerere OborirhovoDepartment of Biochemistry, Faculty of Science, Delta State University, P.M.B.001, Abraka, Nigeria.
Onoriode AkeghwareDepartment of Biochemistry, Faculty of Science, Delta State University, P.M.B.001, Abraka, Nigeria.
Ernest U DurugboDepartment of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Osun State, Nigeria.
Augustine ApiamuDepartment of Biochemistry, Faculty of Science, Delta State University, P.M.B.001, Abraka, Nigeria.
Victor I OlaoyeDepartment of Chemical Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Osun State, Nigeria.
Uchechukwu S EzealigoDepartment of Material Science Engineering, African University of Science and Technology, Abuja, Nigeria.
Nyerhovwo J TonukariDepartment of Biochemistry, Faculty of Science, Delta State University, P.M.B.001, Abraka, Nigeria.
Delta State University · NGRedeemer's University · NGAfrican Institute of Science and Technology · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic lipase (PLP) is an enzyme responsible for the catalytic hydrolysis of fats and its inhibition is relevant for obesity management. Side effects linked with orthodox inhibitors have, however, paved the way for an increased search for safe natural sources. The present study investigated the anti-glycation, anti-inflammatory, and anti-lipase properties of Rauvolfia vomitoria aqueous (ARV), ethanolic (ERV), and methanolic (MRV) leaf extracts coupled with the molecular interactions of selected bioactive compounds with PLP using in vitro and in silico techniques. Phytochemical constituents were characterized using spectroscopic techniques. Drug-likeness and chemical reactivity profile of selected bioactive compounds were analyzed using SwissADME and quantum chemical calculations. FT-IR and GC-MS affirmed the presence of phenolic compounds including 3-phenyl-2-ethoxypropylphthalimide and 5-methyl-2-phenyl-1H-indole. All extracts showed moderate anti-glycation, anti-inflammatory, and lipase inhibitory capacities relative to standard controls. However, MRV exhibited the highest lipase inhibition (IC

Indexed as

Anti-Inflammatory AgentsEnzyme InhibitorsLipaseObesityPlant ExtractsPlant LeavesRauwolfiaAnti-Obesity AgentsGlycosylationHumansMolecular Docking SimulationAnti-Inflammatory AgentsAnti-Obesity AgentsEnzyme InhibitorsLipasePlant ExtractsAnti-glycationAnti-inflammatoryAnti-obesityMolecular dockingRauvolfia vomitoria

Identifiers

PMID38416335
OpenAlexW4392239349

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.