Evidence map›Paper›PMID 38416223›Full record

Trial reportPsychopharmacology2024

The acute effects of cannabis, with and without cannabidiol, on attentional bias to cannabis related cues: a randomised, double-blind, placebo-controlled, cross-over study.

Daniel Hall, Will Lawn, Shelan Ofori, Katie Trinci, Anya Borissova, Claire Mokrysz, Kat Petrilli, Michael A P Bloomfield, Matthew B Wall, Tom P Freeman and 1 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04851392 (Do Adolescents and Adults Differ in Their Acute Subjective, Behavioural and Neural Responses to Cannabis, With and Without Cannabidiol?), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04851392 nacompletednot on this map

Do Adolescents and Adults Differ in Their Acute Subjective, Behavioural and Neural Responses to Cannabis, With and Without Cannabidiol?

TypeinterventionalSponsorUniversity College, LondonRan2019 to 2021Enrolled48ConditionsCannabis, Cannabis Intoxication, Cannabis Use, Cannabis DependenceArmsCannabis with delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), Cannabis with THC without CBD, Placebo cannabis
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Daniel HallClinical Psychopharmacology Unit, Clinical Educational and Health Psychology, University College London, London, UK.
Will LawnClinical Psychopharmacology Unit, Clinical Educational and Health Psychology, University College London, London, UK.
Shelan OforiClinical Psychopharmacology Unit, Clinical Educational and Health Psychology, University College London, London, UK.
Katie TrinciClinical Psychopharmacology Unit, Clinical Educational and Health Psychology, University College London, London, UK.
Anya BorissovaDepartment of Neuroimaging, Institute of Psychiatry Psychology and Neuroscience, King's College, London, UK.
Claire MokryszClinical Psychopharmacology Unit, Clinical Educational and Health Psychology, University College London, London, UK.
Kat PetrilliAddiction and Mental Health Group (AIM), Department of Psychology, University of Bath, London, UK.
Michael A P BloomfieldClinical Psychopharmacology Unit, Clinical Educational and Health Psychology, University College London, London, UK.
Matthew B WallClinical Psychopharmacology Unit, Clinical Educational and Health Psychology, University College London, London, UK.
Tom P FreemanClinical Psychopharmacology Unit, Clinical Educational and Health Psychology, University College London, London, UK.
H Valerie CurranClinical Psychopharmacology Unit, Clinical Educational and Health Psychology, University College London, London, UK. v.curran@ucl.ac.uk.
University College London · GBUCL Biomedical Research Centre · GBUniversity of Bath · GB

Funding

Medical Research Council MR/P012728/1
6 · The paper itself

Abstract

rationaleAttentional bias to drug-related stimuli is hypothesised to contribute towards addiction. However, the acute effects of Δ9-tetrahydrocannabinol (THC) on attentional bias to cannabis cues, the differential response in adults and adolescents, and the moderating effect of cannabidiol (CBD) are unknown.

objectivesOur study investigated (1) the acute effects of vaporised cannabis on attentional bias to cannabis-related images in adults and adolescents and (2) the moderating influences of age and CBD.

methodsWe conducted a randomised, double-blind, placebo-controlled, cross-over study where three weight-adjusted vaporised cannabis preparations: 'THC' (8 mg THC for a 75-kg person), 'THC + CBD' (8 mg THC and 24 mg CBD for a 75-kg person) and PLA (matched placebo). Cannabis was administered on 3 separate days to 48 participants, who used cannabis 0.5-3 days/week: 24 adolescents (12 females, aged 16-17) and 24 adults (12 females, aged 26-29). Participants completed a visual probe task with cannabis cues. Our primary outcome was attentional bias to cannabis stimuli, measured using the differential reaction time to a cannabis vs. neutral probe, on 200-ms trials.

resultsIn contrast to hypotheses, attention was directed away from cannabis cues on placebo, and there was a main effect of the drug (F(2,92) = 3.865, p = 0.024, η

conclusionsAcute THC intoxication eliminated attentional bias away from cannabis cues. There was no evidence of differential response in adolescents compared to adults and no evidence that a moderate vaporised dose of CBD altered the impact of cannabis on attentional bias.

trial registrationThis study was listed with the US National Library of Medicine and registered on ClinicalTrials.gov, URL: Do Adolescents and Adults Differ in Their Acute Response to Cannabis?-Full Text View-ClinicalTrials.gov, registration number: NCT04851392.

Indexed as

Attentional BiasCannabidiolCross-Over StudiesCuesDronabinolAdolescentAdultAge FactorsAttentionCannabisDouble-Blind MethodFemaleHumansMaleYoung AdultCannabidiolDronabinolAdolescenceAttentional biasCannabisCBDTHC

Identifiers

PMID38416223
PMCPMC11106134
OpenAlexW4392237608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.