SynthesisJournal of acquired immune deficiency syndromes (1999)2024
Do Peer Navigators Improve Initiation and Retention in HIV/VH/STI Treatment Programs for People From Key Populations? A Systematic Review of Effectiveness, Values and Preferences, and Cost.
Synthesis in Journal of acquired immune deficiency syndromes (1999), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Implementation components and delivery structures of adolescent peer navigation as a workforce model: a scoping review.BMC global and public health · 2026Pooled it
- Thoughts of Death or Self-injury, Non-same-day ART Initiation, and 2-year Incidence of Disengagement from Care Among People Entering HIV Care in Cameroon.AIDS and behavior · 2026Article
- Experiences and Outcomes of Peer Navigation and Support Interventions for Adolescents on HIV Treatment in Sub-Saharan Africa: A Qualitative Evidence Synthesis.International journal of environmental research and public health · 2026Review
- An Evidence-Based Approach to Facilitating PrEP Initiation Among YMSM: The MyPEEPS Plus mHealth and E-Peer Navigation Intervention.AIDS education and prevention : official publication of the International Society for AIDS Education · 2026Article
- Article
- Association Between Structural and Social Determinants of Health and Cognitive Functioning Among African Americans: the ARCHES Cohort.Journal of racial and ethnic health disparities · 2025Article
- Bacterial and fungal infections in persons who inject drugs.Clinical microbiology reviews · 2025Review
- Provider Perspectives on the Data-to-Suppression Initiative in Ryan White Part A Housing and Behavioral Health Programs.AIDS patient care and STDs · 2025Article
- Article
- A qualitative examination of barriers and facilitators to HIV prevention and treatment for people involved with the criminal justice system.Health & justice · 2025Article
- Integration of Peer Navigators Into Longitudinal Research.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2025Observational
- PLAN-Dementia literacy education and navigation for Korean elders with probable dementia and their caregivers: Rationale, methods, and design of a community-based, randomized, controlled, multi-site clinical trial.Contemporary clinical trials · 2025Article
- Impact of Clinician-Supported Peer Health Navigation on Hospital Resource Utilisation amongst High Risk Adults: A Pragmatic Propensity-Score Matching Study.International journal of integrated careArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundKey populations are disproportionately affected by HIV, viral hepatitis (VH), and sexually transmitted infections (STIs) and face barriers to care. Peer navigation programs are widely used, but evidence supporting their use has not been synthesized.
settingPeer navigation programs for sex workers, men who have sex with men, people who inject drugs, prisoners, and trans and gender diverse people globally.
methodsTo inform World Health Organization guidelines, we conducted a systematic review of effectiveness, values and preferences, and cost studies published between January 2010 and May 2021. We searched CINAHL, PsycINFO, PubMed, and EMBASE; screened abstracts; and extracted data in duplicate. The effectiveness review included randomized controlled trials and comparative observational studies evaluating time to diagnosis or linkage to care, treatment initiation, treatment retention/completion, viral load, cure, or mortality. We assessed risk of bias and summarized findings in GRADE evidence profiles. Values and preferences and cost data were summarized descriptively.
resultsFour studies evaluated the effectiveness of peer navigators for key populations. All were focused on HIV; none were designed for VH or STIs. These studies showed mixed effects on linkage to care, treatment retention/completion, and viral load; no studies measured treatment initiation, cure, or mortality. Two values and preferences studies with community-based organization staff and health workers suggested peer navigators for key populations were acceptable and valued, although continued challenges remained. No cost studies were identified.
conclusionsAlthough limited, available studies provide moderate certainty evidence for benefits of HIV/VH/STI peer navigation programs for key populations. Further evaluations are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.