Evidence map›Paper›PMID 38415976›Full record

ArticleImmunity, inflammation and disease2024

Effects of myeloperoxidase on inflammatory responses with hypoxia in Citrobacter rodentium-infectious mice.

Xiang Gao, Yu Zhang, Qinfang Zhu, Ying Han, Ruhan Jia, Wei Zhang

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Xiang GaoDepartment of Basic Medical Sciences, Medical College, Qinghai University, Xining, Qinghai, China.
Yu ZhangDepartment of Basic Medical Sciences, Medical College, Qinghai University, Xining, Qinghai, China.
Qinfang ZhuResearch Centre for High Altitude Medicine, Research Centre for High Altitude Medicine, Qinghai University, Xining, Qinghai, China.
Ying HanDepartment of Basic Medical Sciences, Medical College, Qinghai University, Xining, Qinghai, China.
Ruhan JiaDepartment of Basic Medical Sciences, Medical College, Qinghai University, Xining, Qinghai, China.
Wei ZhangDepartment of Basic Medical Sciences, Medical College, Qinghai University, Xining, Qinghai, China.ORCID http://orcid.org/0000-0001-6937-5562
NSF NCAR High Altitude Observatory · USQinghai University · CN

Funding

"Kunlun Talent High-end Innovation and Entrepreneurship Talents" Project in Qinghai Province, 2022National Natural Science Foundation of China 31460240National Natural Science Foundation of Qinghai 2022-ZJ-905
6 · The paper itself

Abstract

purposeMyeloperoxidase (MPO) has been identified as a mediator in various inflammatory diseases. Bacterial infection of the intestine and hypoxia can both lead to inflammatory responses, but the role of MPO in these phenomena remains unclear.

methodsBy building the MPO

resultsThe C. rodentium infection and hypoxia caused weight loss, intestinal colitis, and splenic inflammatory cells active proliferation in wild-type mice. MPO deficiency alleviated this phenomenon. MPO

conclusionMPO plays an important role of the inflammatory responses in infectious enteritis and hypoxia in mice, and the loss of MPO may greatly reduce the body's inflammatory responses to fight diseases.

Indexed as

Bacterial InfectionsCitrobacter rodentiumMetabolism, Inborn ErrorsAnimalsChemokinesHypoxiaMicePeroxidaseTumor Necrosis Factor-alphaChemokinesPeroxidaseTumor Necrosis Factor-alphacolitishypoxiainflammatory responsesMPO

Identifiers

PMID38415976
PMCPMC10836036
OpenAlexW4391485383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.