Evidence map›Paper›PMID 38415653›Full record

ArticlemBio2024

A novel lentiviral vector-based approach to generate chimeric antigen receptor T cells targeting

Pappanaicken R Kumaresan, Sebastian Wurster, Karishma Bavisi, Thiago Aparecido da Silva, Paul Hauser, Jordan Kinnitt, Nathaniel D Albert, Uddalak Bharadwaj, Sattva Neelapu, Dimitrios P Kontoyiannis

Open access · goldAbstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. CAR-T therapy: Advances in respiratory diseases.Chinese medical journal pulmonary and critical care medicine · 2025
    Review
  7. Article
  8. Article
  9. Immunoengineering: An Emerging Field in Infectious Diseases.The Journal of infectious diseases · 2025
    Review
  10. Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Pappanaicken R Kumaresan *Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-7788-3241
Sebastian Wurster *Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-7784-7256
Karishma Bavisi *Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Thiago Aparecido da SilvaThe International School of Pharmaceutical Sciences in Araraquara, Sao Paulo, Brazil.ORCID 0000-0001-5017-6539
Paul HauserDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Jordan KinnittDepartment of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Nathaniel D AlbertDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Uddalak BharadwajDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Sattva Neelapu *Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Dimitrios P Kontoyiannis *Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-8051-2940
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Invasive aspergillosis (IA) is a common and deadly mold infection in immunocompromised patients. As morbidity and mortality of IA are primarily driven by poor immune defense, adjunct immunotherapies, such as chimeric antigen receptor (CAR) T cells, are direly needed. Here, we propose a novel approach to generate

Indexed as

AspergillosisReceptors, Chimeric AntigenAnimalsAntifungal AgentsAspergillusAspergillus fumigatusCytokinesHumansInterleukin-2LentivirusLeukocytes, MononuclearMiceT-LymphocytesAntifungal AgentsCytokinesInterleukin-2Receptors, Chimeric AntigenaspergillosisCAR T cellscytokinesimmunotherapymouse modelT lymphocytes

Identifiers

PMID38415653
PMCPMC11005356
OpenAlexW4392232124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.