Evidence map›Paper›PMID 38415559›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2024

Clinical assessment of TGFB1 and HP Relative Gene Expression in the Peripheral Blood of Prostate Cancer Patients.

Mohammed S Yahya, Fatma F Abdel Hameed, Noha H Radwan, Iman A Abdelgawad, Ahmed F Soliman

Open access · goldAbstract read
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In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mohammed S YahyaDepartment of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
Fatma F Abdel HameedDepartment of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
Noha H RadwanDepartment of Clinical and Chemical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.
Iman A AbdelgawadDepartment of Clinical and Chemical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.
Ahmed F SolimanDepartment of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
Ain Shams University · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to assess the relative gene expression level of transforming growth factor-β1 (TGFB1) and haptoglobin (HP) in the peripheral blood of prostate cancer (PCa) patients and evaluate their diagnostic ability.

methodsA total of 125 participants were enrolled in the present study. Among them, 75 PCa patients, 25 benign prostatic hyperplasia (BPH) patients, and 25 healthy volunteers served as the control group. The relative TGFB1 and HP gene expression level was quantified using real-time polymerase chain reaction. Further, free and total PSA levels were determined using electrochemiluminescence assays.

resultsTGFB1 was significantly over-expressed, whereas HP was significantly downregulated in the peripheral blood of PCa patients compared to BPH and control groups (p-value ranges from 0.034 to <0.001). Moreover, the high expression level of TGFB1 was associated with an increased risk of PCa development with OR=1.412 (95%CI: 1.081-1.869, p= 0.012). TGFB1 and HP relative expression levels had lower diagnostic performance to differentiate PCa from normal and BPH individuals compared to PSA, however, the combination of the tested parameters improved the diagnostic efficacy.

conclusionsTGFB1 and HP relative expression have moderate diagnostic efficacy in discriminating patients with PCa from BPH and healthy subjects. Furthermore, over-expression of TGFB1 may contribute to the pathogenesis of PCa.

Indexed as

Prostatic HyperplasiaProstatic NeoplasmsGene ExpressionHaptoglobinsHumansMaleProstate-Specific AntigenTransforming Growth Factor beta1HaptoglobinsProstate-Specific AntigenTGFB1 protein, humanTransforming Growth Factor beta1BiomarkersHaptoglobin (HP)prostate cancer (PCa)Prostate-specific antigen (PSA)Transforming growth factor-β 1 (TGF-β 1)

Identifiers

PMID38415559
PMCPMC11077105
OpenAlexW4392246117

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.