Evidence map›Paper›PMID 38415274›Full record

ArticleFrontiers in cell and developmental biology2024

ATP10A deficiency results in male-specific infertility in mice.

Adriana C Norris, Eugenia M Yazlovitskaya, Tzushan Sharon Yang, Alex Mansueto, John M Stafford, Todd R Graham

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Adriana C NorrisDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, United States.
Eugenia M YazlovitskayaDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, United States.
Tzushan Sharon YangDivision of Comparative Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.
Alex MansuetoDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, United States.
John M StaffordTennessee Valley Healthcare System, Nashville, TN, United States.
Todd R GrahamDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, United States.
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Sex-Specific Risk of Metabolic and Cardiovascular DiseaseR01HL144846 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Michael Stafford · 2019 to 2026
$4.1M
Therapeutic Potential of Estrogen-Regulated Metabolism and Cardiovascular RiskR01DK109102 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STAFFORD, JOHN MICHAEL · 2016 to 2024
$3.6M
Mechanisms of membrane homeostasis through protein and lipid transportR35GM144123 · NIGMS · VANDERBILT UNIVERSITY · PI TODD R GRAHAM · 2022 to 2026
$2.4M
LSM880-Airyscan Confocal Microscope for Large Shared ResourceS10OD021630 · OD · VANDERBILT UNIVERSITY · PI WELLS, K. SAM · 2016 to 2016
$560k
Leica Bond RXS10OD023475 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BOYD, KELLI L. · 2018 to 2018
$213k
Cholesteryl ester transfer protein, a novel mediator of insulin sensitivityI01BX002223 · VA · VETERANS HEALTH ADMINISTRATION · PI STAFFORD, JOHN MICHAEL · 2014 to 2017
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BLRD VA I01 BX002223NCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NHLBI NIH HHS R01 HL144846NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK109102NIDDK NIH HHS U24 DK059637NIGMS NIH HHS R35 GM144123NIH HHS S10 OD021630NIH HHS S10 OD023475
6 · The paper itself

Abstract

Over 8% of couples worldwide are affected by infertility and nearly half of these cases are due to male-specific issues where the underlying cause is often unknown. Therefore, discovery of new genetic factors contributing to male-specific infertility in model organisms can enhance our understanding of the etiology of this disorder. Here we show that murine ATP10A, a phospholipid flippase, is highly expressed in male reproductive organs, specifically the testes and vas deferens. Therefore, we tested the influence of ATP10A on reproduction by examining fertility of

Indexed as

fertilityflippaseglucosylceramideinfertilityknockout mouse modelsmale-specific infertilityP4-ATPasephosphatidylcholine

Identifiers

PMID38415274
PMCPMC10896839
OpenAlexW4391783861

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.